Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
Long-term memory (LTM) can be induced by repeated spaced training trials. Using the weak inhibitory avoidance (wIA) task, we showed that one wIA session does not lead to a 24-h LTM, whereas two identical wIA sessions spaced by 15 min to 6 h induce a 24-h LTM. This LTM promotion depends both on hippocampal protein synthesis and the activity of several kinases. In agreement with the behavioral tagging (BT) hypothesis, our results suggest that the two training sessions induce transient learning tags and lead, via a cooperative effect, to the synthesis of plasticity-related proteins (PRPs) that become available and captured by the tag from the second session. Although ERKs1/2 are needed for PRPs synthesis and CaMKs are required for tag setting, PKA participates in both processes. We conclude that the BT mechanism accounts for the molecular constraints underlying the classic effect of spaced learning on LTM formation.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10372744 | PMC |
| http://dx.doi.org/10.1016/j.isci.2023.107278 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Crowdsourcing a Training Dataset of Question-and-Answer Pairs for AI-Enabled Health Information Tools on Sexually Transmitted Infections: Protocol for a Cross-Sectional Exploratory Survey Study.
JMIR Res Protoc
September 2025
Academy for Health Innovation Uganda, Infectious Diseases Institute, Makerere University, Kampala, Uganda.
Background: Sexually transmitted infections are a significant public health concern, particularly in sub-Saharan Africa, where their prevalence remains high. Promoting awareness and reducing stigma are essential strategies for addressing this challenge, but those affected often have limited access to accurate and culturally appropriate health information. Therefore, innovative solutions are essential to enhance sexual health literacy and encourage informed health-seeking behaviors.
View Article and Find Full Text PDFNeural dynamics of shifting visual attention between objects and locations in early visual cortex.
Cortex
August 2025
Experimental Psychology and Methods, Universität Leipzig, Leipzig, Germany. Electronic address:
Effects of location- and object-based attention on sensory processing have been mostly studied in isolation leaving the relations between them less well understood. In an EEG experiment, temporal dynamics of location- and object-based attention were investigated with a probabilistic spatial cueing task to test temporal differences between sensory enhancement of two locations in one object. Stimuli consisted of two vertical rectangles/bars filled with a random noise pattern.
View Article and Find Full Text PDFSpectroscopy and Theory of Acetylene Coupling Reactions in Ti(CH) Complexes.
J Phys Chem A
September 2025
Department of Chemistry, University of Georgia, Athens, Georgia 30602, United States.
Ti(CH) complexes produced by laser vaporization in a supersonic expansion are investigated with mass spectrometry, infrared laser photodissociation spectroscopy, and UV laser photodissociation. The mass distributions of the cluster ions produced are found to vary significantly with the sample rod mounting configuration in the source. For infrared spectroscopy experiments, the so-called "offset" rod mounting produces colder conditions than the "cutaway" configuration, which allows tagging the ions with one or more argon atoms for the = 1 and 2 complexes.
View Article and Find Full Text PDFMagnetic Targeting of AAV Gene Therapy for Inner Ear Following Systemic Delivery: Preliminary Findings and Transduction Pattern in Rat Cochlea.
J Assoc Res Otolaryngol
September 2025
Biological Sciences Platform, Hurvitz Brain Sciences Program, Sunnybrook Research Institute, Sunnybrook Health Sciences Centre, 2075 Bayview Ave., Room M1 102, Toronto, ON, M4N 3M5, Canada.
Purpose: Delivery of therapeutics to the inner ear is complicated by their inaccessible location and the presence of the blood-labyrinth barrier that restricts most blood-borne compounds from entering the inner ear. This study addresses the challenge of optimal delivery in treating inner ear disease, focusing on magnetic targeting gene therapy using adeno-associated virus (AAV).
Methods: The investigation explores three AAV serotypes (AAV2 Quad Mut, AAV2 pANC80L65, and AAV9 PHP.
Using BONCAT to dissect the proteome of persisters.
mSphere
September 2025
Leiden Institute of Chemistry and The Institute of Chemical Immunology, Leiden University, Leiden, the Netherlands.
Bacterial persisters are a subpopulation of cells that exhibit a transient non-susceptible phenotype in the presence of bactericidal antibiotic concentrations. This phenotype can lead to the survival and regrowth of bacteria after treatment, resulting in relapse of infections. It is also a contributing factor to antibacterial resistance.
View Article and Find Full Text PDF