Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
Fracture healing is a long-term and complex process influenced by a huge variety of factors. Among these, there is a sex/gender disparity. Based on significant differences observed in the outcome of bone healing in males and females, in the present review, we report the main findings, hypotheses and pitfalls that could lead to these differences. In particular, the role of sex hormones and inflammation has been reported to have a role in the observed less efficient bone healing in females in comparison with that observed in males. In addition, estrogen-induced cellular processes such as autophagic cell cycle impairment and molecular signals suppressing cell cycle progression seem also to play a role in female fracture healing delay. In conclusion, it seems conceivable that a complex framework of events could contribute to the female bias in bone healing, and we suggest that a reappraisal of the compelling factors could contribute to the mitigation of sex/gender disparity and improve bone healing outcomes.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10376157 | PMC |
| http://dx.doi.org/10.3390/biology12070993 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Effects of isotretinoin on bone dynamics in the craniomaxillofacial region: a systematic review of preclinical evidence.
Eur Arch Paediatr Dent
September 2025
Araçatuba School of Dentistry, São Paulo State University - UNESP, Araçatuba, Brazil.
Purpose: This systematic review provides a critical evaluation, synthesis of the existing literature on isotretinoin's effects on craniomaxillofacial bone.
Methods: Following the PRISMA guidelines and registered in PROSPERO, the review was conducted in August 2024 across various databases. Eligible in vivo studies were analysed for their assessment of isotretinoin's effects on craniomaxillofacial bone.
[Biphasic plate-Controlled instability in fracture healing].
Unfallchirurgie (Heidelb)
September 2025
Klinik für Unfall‑, Hand- und Wiederherstellungschirurgie, Universitätsklinikum Münster, Albert-Schweitzer-Campus 1, Gebäude W1, 48149, Münster, Deutschland.
The bony consolidation of fractures depends on various factors. Under optimal conditions fracture healing takes place within a few weeks. An essential requirement for fracture healing is the restoration of adequate biomechanical stability with an interfragmentary movement which is as ideal as possible.
View Article and Find Full Text PDFRegeneration or Repair? Evaluating Foreign Material in Periodontal Healing.
J Periodontal Res
September 2025
Foundation for Oral Rehabilitation (FOR), Lucerne, Switzerland.
Comparative clinical efficacy of nickel-titanium shape memory staples versus miniplate for Bartoníček-Rammelt type III and IV posterior malleolar fractures. A retrospective analysis of 47 consecutive patients treated between January 2022 and June 2024 documented operative time, intraoperative blood loss, fluoroscopy times, healing time, complications, postoperative fracture gap distance (mm), and articular surface step-off (mm) at the ankle joint. Ankle function was assessed using the American Orthopaedic Foot and Ankle Society (AOFAS) ankle-hindfoot score, the Manchester-Oxford Foot Questionnaire (MOXFQ), and range of motion measurements at 3, 6, 12, and 14 months.
View Article and Find Full Text PDFEffect of time and local factors on the stability of hydrophilic self-tapping tissue-level implants: 1-year prospective study.
Int J Oral Implantol (Berl)
September 2025
Purpose: To evaluate changes in implant stability quotient values of hydrophilic tissue-level implants over time, and to investigate the influence of local factors on variations in these values.
Methods: Fifty tapered, self-tapping, tissue-level implants with a hydrophilic surface were placed and monitored for 12 months. Implant stability quotient values were recorded at the time of insertion (T0) and monthly thereafter for 12 months.