98%
921
2 minutes
20
Coexisting malignancies is not only an uncommon event but, it can also represent a medical challenge. Its complexity relies on the difficulty of management and the need for personalized and prioritized therapeutic approaches, on the one hand, and in the potential misdiagnosis of recurrence or even a de novo disease, on the other. Here, we present a case of a 69-year-old patient, who was initially diagnosed with a chronic myelomonocytic leukemia (CMML), followed by monoclonal gammopathy of uncertain significance (MGUS). Few years later, the patient developed Hodgkin's lymphoma (HL), and a new mutation, previously undocumented in the medical literature, was also detected. As a conclusion, we can say that the decision must be taken with caution and must be based on two major factors: 1- The rapid evolution of malignancies: give priority to treating the most rapid/life-threatening disease. 2- Prioritize the treatment of symptomatic disease and/or that which may most improve patients' quality of life.
Download full-text PDF |
Source |
---|---|
http://dx.doi.org/10.1016/j.retram.2023.103403 | DOI Listing |
Cureus
August 2025
Department of Internal Medicine, Maimonides Medical Center, Brooklyn, USA.
Brucellosis is a neglected zoonotic infection in Nepal that is often underdiagnosed, particularly in regions considered to have low prevalence. Its presentation can mimic autoimmune or hepatic disorders, complicating timely diagnosis and management. Coexistence with hereditary conditions such as Gilbert syndrome can further obscure the clinical picture.
View Article and Find Full Text PDFAnal Chem
September 2025
College of Chemistry and Chemical Engineering, Central South University, Hunan, Changsha 410083, China.
While deep learning-enhanced Raman spectroscopy enables rapid sample analysis, model portability among spectrometers remains hindered by systematic interdevice variations. In this study, a Low-Rank Adaptation-based Calibration Transfer method (LoRA-CT) is proposed to perform parameter-efficient fine-tuning of deep learning models across spectrometers. By decomposing weight updates into low-rank matrices, LoRA-CT achieves superior calibration transfer with minimal samples, reducing trainable parameters by 600× compared to full parameter fine-tuning.
View Article and Find Full Text PDFPhotodiagnosis Photodyn Ther
September 2025
China Medical University, Hsin-Chu Hospital. Electronic address:
Background: Managing stage IV thymoma with pleural spread or recurrence remains a complex clinical challenge. While complete resection is considered essential for achieving long-term survival, its feasibility and outcomes vary. Inspired by surgical strategies used in malignant pleural mesothelioma, we applied a multimodal approach combining extensive thymectomy, cytoreductive lung-preserving pleurectomy/decortication, and intraoperative photodynamic therapy (PDT) to enhance local control and survival outcomes.
View Article and Find Full Text PDFIEEE Trans Neural Netw Learn Syst
September 2025
In this article, we first tackle a more realistic domain adaptation (DA) setting: source-free blending-target DA (SF-BTDA), where we cannot access to source-domain data while facing mixed multiple target domains without any domain labels in prior. Compared to existing DA scenarios, SF-BTDA generally faces the coexistence of different label shifts in different targets, along with noisy target pseudolabels generated from the source model. In this article, we propose a new method called evidential graph contrastive alignment (EGCA) to decouple the blending-target domain and alleviate the effect of noisy target pseudolabels.
View Article and Find Full Text PDFCureus
August 2025
Dermatology, Centro Medico Nacional 20 de Noviembre, Instituto de Seguridad y Servicios Sociales de los Trabajadores del Estado, Mexico City, MEX.
Primary cutaneous diffuse large B-cell lymphoma, leg type (PCDLBCL-LT), is an uncommon and aggressive subtype of cutaneous B-cell lymphoma, typically affecting elderly women and predominantly involving the lower extremities. Its diagnosis relies on immunohistochemical profiling and clinical presentation. We report a rare case of a 45-year-old male presenting initially with scalp and supraciliary plaques.
View Article and Find Full Text PDF