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Variational Bayes (VB) inference algorithm is used widely to estimate both the parameters and the unobserved hidden variables in generative statistical models. The algorithm-inspired by variational methods used in computational physics-is iterative and can get easily stuck in local minima, even when classical techniques, such as deterministic annealing (DA), are used. We study a VB inference algorithm based on a nontraditional quantum annealing approach-referred to as quantum annealing variational Bayes (QAVB) inference-and show that there is indeed a quantum advantage to QAVB over its classical counterparts. In particular, we show that such better performance is rooted in key quantum mechanics concepts: i) The ground state of the Hamiltonian of a quantum system-defined from the given data-corresponds to an optimal solution for the minimization problem of the variational free energy at very low temperatures; ii) such a ground state can be achieved by a technique paralleling the quantum annealing process; and iii) starting from this ground state, the optimal solution to the VB problem can be achieved by increasing the heat bath temperature to unity, and thereby avoiding local minima introduced by spontaneous symmetry breaking observed in classical physics based VB algorithms. We also show that the update equations of QAVB can be potentially implemented using ⌈log⌉ qubits and 𝒪() operations per step, where is the number of values hidden categorical variables can take. Thus, QAVB can match the time complexity of existing VB algorithms, while delivering higher performance.
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http://dx.doi.org/10.1073/pnas.2212660120 | DOI Listing |
Biostatistics
December 2024
Department of Biostatistics, Brown University, 121 S Main Street, Providence, RI, 02903, United States.
Brain functional connectivity (FC), the temporal synchrony between brain networks, is essential to understand the functional organization of the brain and to identify changes due to neurological disorders, development, treatment, and other phenomena. Independent component analysis (ICA) is a matrix decomposition method used extensively for simultaneous estimation of functional brain topography and connectivity. However, estimation of FC via ICA is often sub-optimal due to the use of ad hoc estimation methods or temporal dimension reduction prior to ICA.
View Article and Find Full Text PDFComput Biol Med
September 2025
Institute of Cognitive Neurology and Dementia Research (IKND), Otto-von-Guericke University (OVGU), Magdeburg, Germany; German Center for Neurodegenerative Diseases (DZNE), Magdeburg, Germany.
This study introduces the Structural MRI-based Alzheimer's Disease Score (SMAS), a novel index intended to quantify Alzheimer's Disease (AD)-related morphometric patterns using a deep learning Bayesian-supervised Variational Autoencoder (Bayesian-SVAE). The SMAS index was constructed using baseline structural MRI data from the DELCODE study and evaluated longitudinally in two independent cohorts: DELCODE (n=415) and ADNI (n=190). Our findings indicate that SMAS has strong associations with cognitive performance (DELCODE: r=-0.
View Article and Find Full Text PDFJ Am Chem Soc
August 2025
Beijing National Laboratory for Condensed Matter Physics, Institute of Physics, Chinese Academy of Sciences, Beijing 100190, China.
Understanding rapid, nonequilibrium dynamics of single proteins in lipid membranes is crucial but challenging. This study advances fluorescence lifetime analysis by developing a computationally efficient variational Bayesian framework for photon-by-photon hidden Markov modeling. It enables robust and accurate model selection, facilitating real-time tracking of state evolution of a molecule within a brief time frame.
View Article and Find Full Text PDFEntropy (Basel)
June 2025
Intelligence Engineering and Mathematics Institute, Liaoning Technical University, Fuxin 123000, China.
Friston proposed the Minimum Free Energy Principle (FEP) based on the Variational Bayesian (VB) method. This principle emphasizes that the brain and behavior coordinate with the environment, promoting self-organization. However, it has a theoretical flaw, a possibility of being misunderstood, and a limitation (only likelihood functions are used as constraints).
View Article and Find Full Text PDFBMC Cancer
July 2025
Department of Neurosurgery, Affiliated Hospital of Xuzhou Medical University, No. 99, Huaihai West Road, Xuzhou, 221000, China.
Purpose: To predict the 1p/19q molecular status of Lower-grade glioma (LGG) patients nondestructively, this study developed a deep learning (DL) approach using radiomic to provide a potential decision aid for clinical determination of molecular stratification of LGG.
Methods: The study retrospectively collected images and clinical data of 218 patients diagnosed with LGG between July 2018 and July 2022, including 155 cases from The Cancer Imaging Archive (TCIA) database and 63 cases from a regional medical centre. Patients' clinical data and MRI images were collected, including contrast-enhanced T1-weighted images and T2-weighted images.