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Studies of human exploration frequently cast people as serendipitously stumbling upon good options. Yet these studies may not capture the richness of exploration strategies that people exhibit in more complex environments. Here we study behaviour in a large dataset of 29,493 players of the richly structured online game 'Little Alchemy 2'. In this game, players start with four elements, which they can combine to create up to 720 complex objects. We find that players are driven not only by external reward signals, such as an attempt to produce successful outcomes, but also by an intrinsic motivation to create objects that empower them to create even more objects. We find that this drive for empowerment is eliminated when playing a game variant that lacks recognizable semantics, indicating that people use their knowledge about the world and its possibilities to guide their exploration. Our results suggest that the drive for empowerment may be a potent source of intrinsic motivation in richly structured domains, particularly those that lack explicit reward signals.
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http://dx.doi.org/10.1038/s41562-023-01661-2 | DOI Listing |
ACS Bio Med Chem Au
August 2025
Department of Biochemistry and Biophysics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, United States.
RNA biology exemplifies functional heterogeneitydistinct RNA classes are expressed in tissue- and development-specific contexts, adopt dynamic conformational ensembles, and form intricate, context-dependent interactions with proteins and other molecules to regulate gene expression. These features make RNA a powerful metaphor for reimagining scientific culture. Just as RNA achieves biological complexity through versatility, feedback loops, and communication, research environments thrive when they support dynamic interactions, structural adaptability, and the intentional inclusion of divergent perspectives and experiences.
View Article and Find Full Text PDFNat Commun
August 2025
Department of Pharmacology and Physiology, School of Medicine, University of Maryland, Baltimore, MD, USA.
Through its widespread reciprocal connections with the cerebral cortex, the claustrum is implicated in sleep and waking cortical network states. Yet, basic knowledge of neuromodulation in this structure is lacking. The claustrum is richly innervated by serotonergic fibers, expresses serotonin receptors, and is suggested to play a role in the ability of psilocybin, which is metabolized to the non-specific serotonin receptor agonist psilocin, to disrupt cortex-wide network states.
View Article and Find Full Text PDFJ Colloid Interface Sci
August 2025
School of Materials and Energy, Southwest University, Chongqing 400715, PR China; Chongqing Key Lab for Battery Materials and Technologies, Southwest University, Chongqing 400715, PR China. Electronic address:
Binders are key components for maintaining the structural integrity of electrodes and improving electrochemical stability of lithium-ion batteries (LIBs). Currently, polyvinylidene fluoride (PVDF) serves as the main binder of LIBs, but suffer a number of drawbacks, including its high fluorine content, the use of organic toxic solvents (N-methylpyrrolidone, NMP) during processing, poor weak adhesion, low mechanical flexibility and non-recyclability. To address the shortcomings of PVDF binder, herein, a fluorine-free, waterborne binder acrylamide (AM) and itaconic (IA) acid grafted carboxylated chitosan (CS) copolymer (CMA), featuring a three-dimensional hydrogen-bonded cross-linking network, is proposed.
View Article and Find Full Text PDFInt J Biol Macromol
September 2025
Department of Burn Plastic and Wound Repair, Ganzhou Hospital-Nanfang Hospital, Southern Medical University, Ganzhou 341000,China. Electronic address:
Chronic diabetic wounds pose significant clinical challenges due to persistent inflammation, impaired neovascularization, and recurrent infections. This study is based on the natural three-dimensional porous structure and bioactive components of eggshell membranes (ESM), on which we assembled an in situ Cu@MOF, richly loaded with Cu and Zn, to create a multifunctional wound dressing (ESM@Cu-MOF). The characterization results demonstrated that the ESM@Cu-MOF exhibited excellent antibacterial performance and cell compatibility, with pH-responsive ion release characteristics.
View Article and Find Full Text PDFPremise: With the advent of inexpensive nucleic acid sequencing and automated annotation at the level of basic functionality, the central problem of enzyme discovery is no longer finding active sequences, it is determining which ones are suitable for further study. This requires annotation that goes beyond sequence similarity to known enzymes and provides information at the sequence and structural levels.
Methods: Here we introduce a workflow for generating highly informative, richly annotated sequence alignments from protein sequence data.