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Article Abstract
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10529134 | PMC |
| http://dx.doi.org/10.1016/j.jdermsci.2023.06.006 | DOI Listing |
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Article Synopsis
- - Immunotherapy harnesses innate immune sensors like cGAS and STING to fight tumors, and combining these with chemotherapy drugs such as doxorubicin (DOX) and reversine (REV) can enhance anti-tumor effects through the cGAS/STING pathway.
- - Researchers developed hybrid lipid nanovesicles (LEV@DOX@REV) that effectively deliver these drugs to tumors, utilizing the natural "homing" ability of cell membranes to target cancerous tissues.
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Department of Dermatology, Kosin University College of Medicine, Busan, Republic of Korea. Electronic address:
A screening of inhibitors targeting the receptor kinase FERONIA reveals small molecules that enhance plant root immunity.
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State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Biology, Hunan University, Changsha, China.
Receptor-like kinases (RLKs) constitute the largest receptor family involved in the regulation of plant immunity and growth, but small-molecule inhibitors that target RLKs to improve agronomic traits remain unexplored. The RLK member FERONIA (FER) negatively regulates plant resistance to certain soil-borne diseases that are difficult to control and cause huge losses in crop yields and economy. Here, we identified 33 highly effective FER kinase inhibitors from 1494 small molecules by monitoring FER autophosphorylation in vitro.
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