Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
Low bone density, fragility, and microarchitectural disintegration are the symptoms of osteoporosis. An imbalance between bone growth and resorption can lead to osteoporosis. This study evaluated the effects of amino-calcium (AC) on bone protection in ovariectomized control group (NC) rats. Amino-calcium (AC) was characterized using Fourier-transform infrared spectroscopy (FT-IR), energy-dispersive X-ray spectroscopy (EDS), and nuclear magnetic resonance spectroscopy analyses (NMR). After determining the biocompatibility of amino-calcium (AC) with MC3T3-E1 cells, alkaline phosphatase staining revealed significant changes on day 7. Three of the four groups underwent ovariectomy, whereas one group received a placebo. On micro-computed tomography, in vivo, data showed increased bone volume fraction in the femoral head and shaft areas in the amino-calcium (AC) group. Hematoxylin and eosin staining showed a bone mass and architectural protection in the amino-calcium (AC) group compared with the calcium carbonate and OVX control group. RNA sequencing analysis revealed high expression of osteogenesis-related genes in MC3T3-E1 cells. RNA sequencing revealed a significant fold change in the expression of integrin-binding sialoprotein (IBSP), bone gamma-carboxyglutamate proteins 1 and 2(BGLAP1 and BGLAP2), and periostin (POSTN). The study concluded that supplementing the OVX rats with calcium enhanced bone protection.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.lfs.2023.121927 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Recent advances in computational strategies for allosteric site prediction: Machine learning, molecular dynamics, and network-based approaches.
Drug Discov Today
September 2025
Department of Pharmaceutical and Artificial-Intelligence Sciences, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China; Key Laboratory of Protection, Development and Utilization of Medicinal Resources in Liupanshan Area, Ministry of Education, Peptide & Protein Drug Research Cen
The landscape of allosteric drug discovery is undergoing a transformative shift, driven by the integration of three computational approaches: machine learning (ML), molecular dynamics (MD) simulations, and network theory. ML identifies potential allosteric sites from multidimensional biological datasets; MD simulations, empowered by enhanced sampling algorithms, reveal transient conformational states; and network analyses uncover communication pathways, further aiding in site identification. Their synergy enables rational allosteric modulator design.
View Article and Find Full Text PDFStage-Dependent Effects of Moderate Treadmill Exercise on Cartilage Preservation and Subchondral Bone Remodeling in Mouse Osteoarthritis Progression.
Osteoarthritis Cartilage
September 2025
Center for Translational Medicine, Departments of Medicine and Orthopaedic Surgery, Sidney Kimmel Medical College, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, United States; Department of Orthopaedic Surgery, Sidney Kimmel Medical College, Thomas Jefferson University, Philadelphia
Objective: Exercise is widely advocated for osteoarthritis (OA) treatment; however, its effectiveness across disease stages, particularly in advanced OA, remains inconclusive. This study assessed the impact of treadmill exercise at distinct OA stages to determine optimal intervention timing.
Methods: Following validation of a moderate treadmill protocol, 96 male C57BL/6J mice underwent destabilization of the medial meniscus (DMM) surgery on the right knee and sham surgery on the left.
Benzene induces myelodysplasia and hematotoxicity via ferroptosis induction and downregulation of GPX4.
Arch Biochem Biophys
September 2025
Department of Hematology, Shidong Hospital, Yangpu District, Shidong Hospital Affiliated to University of Shanghai for Science and Technology, Shanghai, China 200433. Electronic address:
Background: Benzene, a ubiquitous industrial chemical, is a well-established environmental toxin associated with hematological disorders such as myelodysplastic syndromes (MDS) and acute myeloid leukemia (AML), which are characterized by impaired hematopoiesis and bone marrow failure. This study investigates the role of ferroptosis, an iron-dependent form of cell death, in benzene-induced hematotoxicity, focusing on the repression of glutathione peroxidase 4 (GPX4), a critical regulator of ferroptosis.
Materials And Methods: Male C57BL/6 mice were exposed to benzene at various doses over six weeks.
Therapeutic potential of COMP and TIMP-3 in preserving cartilage integrity compromised by proteases: A histo-mechanical study.
J Mech Behav Biomed Mater
September 2025
Department of Mechanical Engineering, University of Louisiana at Lafayette, LA, 70503, USA. Electronic address:
Matrix metalloproteinases (MMPs) and a disintegrin and metalloproteinase with thrombospondin motifs (ADAMTS) significantly impact articular cartilage biomechanical properties in osteoarthritis (OA). However, comprehensive understanding of biomechanical responses and the efficacy of potential therapeutic interventions remains limited. This study investigates how MMPs and ADAMTS synergistically degenerate cartilage biomechanical properties under different loading conditions, and evaluates the preventive role of cartilage oligomeric matrix protein (COMP) and tissue inhibitor of metalloproteinase-3 (TIMP-3).
View Article and Find Full Text PDFDimethyl fumarate mitigates osteoarthritis progression through Nrf2 activation-mediated suppression of oxidative stress and subchondral osteoclastogenesis.
Int Immunopharmacol
September 2025
Department of Orthopaedics, The Second Affiliated Hospital and Yuying Childrens Hospital of Wenzhou Medical University, Wenzhou, Zhejiang Province, China; Key Laboratory of Orthopaedics of Zhejiang Province, Wenzhou, Zhejiang Province, China. Electronic address:
Osteoarthritis (OA) is a degenerative joint disease associated with imbalanced subchondral bone remodeling, and there is currently no curative treatment available. In OA, excessive osteoclast activity leads to bone loss and inflammatory responses. Dimethyl fumarate (DMF), an Nrf2 activator already used in treating psoriasis and multiple sclerosis, may alleviate OA by suppressing oxidative stress and osteoclastogenesis.
View Article and Find Full Text PDF