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The increasing prevalence of metabolic syndrome is associated with major health and socioeconomic consequences. Currently, physical exercise, together with dietary interventions, is the mainstay of the treatment of obesity and related metabolic complications. Although exercise training includes different modalities, with variable intensity, duration, volume, or frequency, which may have a distinct impact on several characteristics related to metabolic syndrome, the potential effects of exercise timing on metabolic health are yet to be fully elucidated. Remarkably, promising results with regard to this topic have been reported in the last few years. Similar to other time-based interventions, including nutritional therapy or drug administration, time-of-day-based exercise may become a useful approach for the management of metabolic disorders. In this article, we review the role of exercise timing in metabolic health and discuss the potential mechanisms that could drive the metabolic-related benefits of physical exercise performed in a time-dependent manner.
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http://dx.doi.org/10.1111/obr.13599 | DOI Listing |
Osteoarthritis Cartilage
September 2025
Center for Translational Medicine, Departments of Medicine and Orthopaedic Surgery, Sidney Kimmel Medical College, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, United States; Department of Orthopaedic Surgery, Sidney Kimmel Medical College, Thomas Jefferson University, Philadelphia
Objective: Exercise is widely advocated for osteoarthritis (OA) treatment; however, its effectiveness across disease stages, particularly in advanced OA, remains inconclusive. This study assessed the impact of treadmill exercise at distinct OA stages to determine optimal intervention timing.
Methods: Following validation of a moderate treadmill protocol, 96 male C57BL/6J mice underwent destabilization of the medial meniscus (DMM) surgery on the right knee and sham surgery on the left.
J Foot Ankle Res
September 2025
La Trobe Rural Health School, La Trobe University, Bendigo, Australia.
Background: Acute Charcot neuroarthropathy (CN) is a rare but serious complication of diabetes that requires timely diagnosis and evidence-based management to prevent long-term disability. In regional or rural settings, delivering evidence-based care is particularly challenging due to systemic and contextual barriers.
Objective: To explore the perceptions of patients and health professionals about assessment, diagnosis and management of acute CN in a regional Victorian health service.
Sports Med
September 2025
Harvard Medical School, Boston, USA.
Background: Physical training influences competitive marathon performance, including training volume and training frequency changes (TFCs) pre-race. Training intensity distribution (i.e.
View Article and Find Full Text PDFBr Med Bull
September 2025
Department of Orthopaedics and Trauma Surgery, Academic Hospital of Bolzano (SABES-ASDAA), Via Lorenzo Boehler 5, Gries-San Quirino, Bolzano 39100, South Tyrol, Italy.
Introduction: To improve patient satisfaction after total knee arthroplasty (TKA), retention of the infrapatellar fat pad (IPFP) is advocated.
Source Of Data: Recently published literature identified from PubMed, EMBASE, Scopus, and Google Scholar.
Areas Of Agreement: TKA is routinely performed in patients with end-stage joint osteoarthritis, but 18% to 11% of patients are unsatisfied after surgery.
BMJ Open
September 2025
Department for Life Quality Studies, Alma Mater Studiorum University of Bologna, Rimini, Italy.
Objective: This study aims to analyse the barriers and facilitators towards an implementation of active breaks (ABs) intervention inside the workplace.
Methods: This study used a mixed-methods approach, incorporating virtual focus groups and an online questionnaire, conducted among the workers of Alma Mater Studiorum - University of Bologna (Italy). A total of 30 participants (N=30), including administrative and academic staff, PhD candidates, specialised trainees and research fellows, were involved in the study.