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We present an optical method for the manipulation of microparticles using two tilted-focused beams. First, the action on the microparticles is studied with a single tilted-focused beam. The beam is used to drive the directional motion of a dielectric particle. When the optical scattering force is larger than the optical gradient force, the particle is pushed to the tilted side of the optical axis by the optical force. Second, two tilted-focused beams with the same power and complementary tilt angles are used to assemble an optical trap. The trap can be used to realize the optical trapping of the dielectric particles and opto-thermal trapping of the light absorbing particles. The trapping mechanism is the balance of the forces exerted on the particles, including the optical scattering force, optical gradient force, gravity, and thermal gradient force. The trap center is away from the focal spots, which effectively prevents the laser beam from being focused on the trapped object.
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http://dx.doi.org/10.1063/5.0155049 | DOI Listing |
Langmuir
September 2025
School of Biomedical Engineering, Anhui Medical University, Hefei 230032, China.
Optical manipulation techniques have been widely applied in the biomedical field. However, the key issues limiting the efficiency of optical manipulation techniques are the weak driving force of optical scattering and the small working range of optical gradient forces. The optothermal Marangoni convection enables effective control of flow fields through optical means, and particle manipulation based on this mechanism offers advantages such as a wide working range, strong driving force, and high flexibility.
View Article and Find Full Text PDFJ Chem Theory Comput
September 2025
Materials DX Research Center, National Institute of Advanced Industrial Science and Technology, Tsukuba Central 2, 1-1-1 Umezono, Tsukuba, Ibaraki 305-8568, Japan.
The quantum mechanics/molecular mechanics (QM/MM) method is a powerful approach for investigating solid surfaces in contact with various types of media, since it allows for flexible modeling of complex interfaces while maintaining an all-atom representation. The mean-field QM/MM method is an average reaction field model within the QM/MM framework. The method addresses the challenges associated with the statistical sampling of interfacial atomic configurations of a medium and enables efficient calculation of free energies.
View Article and Find Full Text PDFPLoS One
September 2025
Mechanical and Nuclear Engineering Department, Khalifa University of Science and Technology, Abu Dhabi, United Arab Emirates.
Sectionally nonlinearly functionally graded (SNFG) structures with triply periodic minimal surface (TPMS) are considered ideal for bone implants because they closely replicate the hierarchical, anisotropic, and porous architecture of natural bone. The smooth gradient in material distribution allows for optimal load transfer, reduced stress shielding, and enhanced bone ingrowth, while TPMS provides high mechanical strength-to-weight ratio and interconnected porosity for vascularization and tissue integration. Wherein, The SNFG structure contains sections with thickness that varies nonlinearly along their length in different patterns.
View Article and Find Full Text PDFNeurosurgery
September 2025
Department of Neurosurgery, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Background And Objectives: Social determinants of health (SDOH) are key drivers of health inequities, shaping disparities in patient outcomes that must be addressed. This study examines the association between SDOH and suspected child abuse (SCA) in pediatric patients sustaining traumatic brain injury (TBI), leveraging newly proposed Centers for Disease Control and Prevention (CDC)/PLACES measures to identify the most contributing measure to SCA.
Methods: A retrospective review of our institutional database (2016-2023) identified pediatric TBI cases (18 years and younger) using International Classification of Diseases, 10th Revision codes based on a modified CDC framework.
Nat Commun
September 2025
Department of Chemical Science and Engineering, School of Materials and Chemical Technology, Institute of Science Tokyo, Nagatsuta-cho, Midori-ku, Yokohama, Japan.
The research and implementation of portable and low-cost analytical devices that possess high reproducibility and ease of operation is still a challenging task, and a growing field of importance, within the analytical research. Herein, we report the concept, design and optimization of a microfluidic device based on electrochemiluminescence (ECL) detection that can be potentially operated without electricity for analytical purposes. The device functions exploiting the concept of streaming potential-driven bipolar electrochemistry, where a potential difference, generated from the flow of an electrolyte through a microchannel under the influence of a pressure gradient, is the driving force for redox reactions.
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