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This study aimed to evaluate sarcopenia and locomotive syndrome in Korean elderly patients, analyze the closely related factors, and determine the threshold for distinguishing participants with sarcopenia, locomotive syndrome, and non-disease. To this end, we enrolled 210 subjects aged 65 years or more and classified them into the sarcopenia ( = 36) and locomotive syndrome ( = 164) groups; a control group was also included ( = 10). We evaluated the characteristics of these patients using the Timed Up and Go (TUG) test and Berg Balance Scale (BBS) and performed statistical analysis. Our findings showed statistically significant differences between the groups, leading to the derivation of a significant threshold value. The threshold value of the TUG test between the control and locomotive syndrome groups was 9.47 s; the threshold value of the BBS was 54 points, respectively. The threshold value of the TUG test between the locomotive syndrome and sarcopenia groups was 10.27 s, and the threshold value of the BBS was 50 points, respectively. These findings suggest that sarcopenia is closely related to locomotive syndrome, and that sarcopenia and locomotive syndrome can be identified using a physical therapy diagnostic evaluation tool.
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http://dx.doi.org/10.3390/ijerph20126098 | DOI Listing |
Prog Rehabil Med
September 2025
Department of Orthopaedics, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan.
Objectives: : This study aimed to assess the qualitative effects of locomotion training (LT) on articular cartilage using magnetic resonance imaging T1ρ mapping.
Methods: : Fifteen patients with early knee osteoarthritis participated in the study. They performed a series of exercises, including one-leg stands, squats, heel raises, and front lunges, on a daily basis for 12 weeks.
Behav Brain Res
September 2025
Department of Pharmacology, Research Block B, Post Graduate Institute of Medical Education and Research (PGIMER), Chandigarh 160012, India. Electronic address:
Infantile Epileptic Spasms Syndrome (IESS), also referred to as West syndrome, is a severe epileptic disorder that emerges during early childhood. It is marked by characteristic epileptic spasms, developmental stagnation or regression, and a distinctive electroencephalogram (EEG) pattern known as hypsarrhythmia. To better understand the underlying mechanisms of IESS, various genetic and chemically induced animal models have been developed.
View Article and Find Full Text PDFACS Chem Neurosci
September 2025
Key Laboratory of Resource Biology and Biotechnology in Western China, Ministry of Education, The College of Life Sciences, Northwest University, Xi'an 710069, P.R. China.
Developmental epileptic encephalopathies (DEEs), including Dravet syndrome (DS), require antiseizure medications (ASMs) that balance efficacy with developmental safety. There is an urgent clinical need for novel therapeutic agents that combine potent anticonvulsant activity with developmental safety. β-Asarone, an active constituent of plants, has demonstrated antiepileptic potential, but its toxicities severely limit clinical application.
View Article and Find Full Text PDFPLoS One
September 2025
Department of Rehabilitation Sciences, Faculty of Health and Social Sciences, The Hong Kong Polytechnic University, Hong Kong.
Objective: Backward walking may promote the preferential recruitment of lumbar extensors to optimize flexed spinal posture adopted LBP flexion subgroup. This cross-sectional study investigated the backward-walking exercise on a) real-time muscle activation, and b) its immediate effect on back pain intensity, movement control and lumbopelvic muscle activation in individuals with chronic non-specific LBP characterized with lumbar flexion syndrome.
Method: Thirty adults with chronic non-specific LBP with clinical manifestation of flexion syndrome received assessments of their movement control at static standing and during the five-minute forward walking test, conducted before and after a 15-minute treadmill walking training in forward or backward direction (as the immediate effect), while real-time adaptation of the lumbopelvic muscles during walking training was also evaluated.
Eur Spine J
September 2025
Department of Orthopaedic Surgery, School of Medicine, Fukushima Medical University, 960-1295, 1 Hikarigaoka, Fukushima City, Japan.