98%
921
2 minutes
20
An injectable nanocomposite alginate-Ca hydrogel embedded with melittin and polyaniline nanofibers was fabricated for Ca-overload and photothermal combination cancer therapy. Melittin disrupts the cell membranes and enhances Ca influx significantly, improving Ca-overload treatment, while the polyaniline nanofibers endow the hydrogel with glutathione (GSH) depletion and photothermal ability.
Download full-text PDF |
Source |
---|---|
http://dx.doi.org/10.1039/d3cc01867a | DOI Listing |
RSC Adv
September 2025
Department of Nanobiochemistry, Frontiers of Innovative Research in Science and Technology (FIRST), Konan University 7-1-20 Minatojima-minamimachi, Chuo-ku Kobe 650-0047 Japan
The application of nanoscale metal-organic frameworks (MOFs) in tissue engineering is receiving increased attention. As three-dimensional scaffolding materials that provide an appropriate extracellular microenvironment supporting the survival, proliferation, and organization of cells play a key role tissue engineering, hybridization of nanoscale MOFs with bulk hydrogels has led to the development of nanoscale MOF-combined hydrogels. However, development of nanoscale MOF-combined hydrogel scaffolds remains challenging.
View Article and Find Full Text PDFComp Biochem Physiol B Biochem Mol Biol
September 2025
Department of Aquatic Animal Medicine, Faculty of Veterinary Medicine, Zagazig University, PO Box 44511, Zagazig, Sharkia, Egypt.
This study investigated the potential for chitosan nanogel (CNG) to mitigate adverse consequences of infection by Shewanella spp. in the Nile tilapia, Oreochromis niloticus. A total of 160 fish (average weight = 27.
View Article and Find Full Text PDFTheranostics
August 2025
State Key Laboratory of Digital Medical Engineering, School of Biological Science and Medical Engineering, Southeast University, Nanjing 210096, China.
The development of hemostatic materials for non-compressible intra-abdominal hemorrhage in complex pre-hospital emergency settings remains a formidable challenge. A novel injectable hydrogel based on mussel-inspired nanocomposite microspheres was designed. The biocompatible hydrogel was formed by hydrating gelatin methacryloyl (GelMA) cryogel microspheres-reinforced with polydopamine (PDA)-intercalated nanoclay-with sterile saline, offering the dual benefits of convenient storage of microspheres and precise delivery to deep bleeding points via injection.
View Article and Find Full Text PDFInt J Pharm
October 2025
CHU Sainte-Justine, Azrieli Research Center, Montréal, QC, Canada; Université de Montréal, Montréal, QC, Canada. Electronic address:
Osteoarthritis (OA) is a widespread cause of physical disability and chronic pain, yet it lacks a pharmacological cure due to the difficulty of delivering drugs to avascular cartilage. We recently developed peptide-grafted nanogels for intra-articular injection that were well tolerated in vivo in healthy equine joints. Hence, this study reports the pharmaceutical aspects of this drug delivery system, which is based on biopolymeric nanohydrogels (nanogels, NG) for the localized, sustained delivery of two peptide antagonists of endothelin-1 (ETA) and bradykinin (BKB1), namely BQ123 and R954.
View Article and Find Full Text PDFCarbohydr Polym
November 2025
Department of Ultrasonic Diagnosis, Department of Orthopedics, Zhujiang Hospital, Southern Medical University, Guangzhou 510282, PR China. Electronic address:
Osteoarthritis (OA), a common chronic joint disorder, is characterized by cartilage degeneration and inflammation. Electrical stimulation has shown promise as a treatment modality for OA, providing pain relief and fostering cartilage regeneration. However, its clinical application still remains limited.
View Article and Find Full Text PDF