An injectable nanocomposite alginate-Ca hydrogel for melittin-assisted Ca-overload and photothermal cancer therapy.

Chem Commun (Camb)

Key Laboratory for Organic Electronics and Information Displays (KLOEID), Jiangsu Key Laboratory for Biosensors, Institute of Advanced Materials (IAM), Jiangsu National Synergistic Innovation Centre for Advanced Materials (SICAM), Nanjing University of Posts & Telecommunications, Nanjing, 210023, Ch

Published: July 2023


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Article Abstract

An injectable nanocomposite alginate-Ca hydrogel embedded with melittin and polyaniline nanofibers was fabricated for Ca-overload and photothermal combination cancer therapy. Melittin disrupts the cell membranes and enhances Ca influx significantly, improving Ca-overload treatment, while the polyaniline nanofibers endow the hydrogel with glutathione (GSH) depletion and photothermal ability.

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http://dx.doi.org/10.1039/d3cc01867aDOI Listing

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