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Background: Superior migration of the humeral head has been linked with rotator cuff dysfunction and glenoid loosening after total shoulder arthroplasty (TSA). We aimed to determine if superior migration was associated with poor shoulder function following anatomic TSA at long-term follow-up.
Methods: In this retrospective cohort study, we reviewed patients undergoing TSA by a single surgeon at an urban, academic institution. To study the effect of superior migration on TSA outcomes, we stratified the cohort by ≥ and <7 mm of acromiohumeral interval (AHI) and compared range of motion and patient reported outcomes (PROs). Clinical variables included preoperative and postoperative forward elevation (FE), internal rotation, external rotation, visual analog scale, American Shoulder and Elbow Surgeons shoulder score, and Simple Shoulder Text score. Radiographic variables included immediate postoperative and long-term follow-up AHI, lateral humeral offset, and glenoid loosening scores.
Results: After applying exclusion criteria, 121 TSAs were included. The mean age was 63.9 ± 9.5 years, and 66 surgeries (55%) were in male patients. The mean follow-up for our cohort was 11.2 years (range, 5-26 years). Nine shoulders underwent revision surgery. All range of motion and PROs improved significantly from preoperative to the most recent postoperative follow-up. The mean AHI immediately following surgery was 10.9 ± 4.1 mm, while the mean AHI at most recent follow-up was 8.4 ± 3.5 mm. Glenoid loosening was observed in 29 (23.8%) shoulders at the most recent follow-up appointment. Although AHI correlated weakly with FE (r = 0.252; P = .006), we did not observe a clear threshold of migration which led to degraded function. Importantly, glenoid loosening was not related to AHI at long-term follow-up (P = .631). None of FE, internal rotation, external rotation, visual analog scale, American Shoulder and Elbow Surgeons shoulder score, Simple Shoulder Text, or revisions were significantly different between patients with ≥ and <7 mm of AHI.
Conclusion: Our results suggest that anatomic TSA provides durable improvements to pain, function, and PROs despite changes to the AHI.
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http://dx.doi.org/10.1016/j.jse.2023.04.033 | DOI Listing |
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September 2025
Key Laboratory of Electrochemical Power Sources of Hubei Province, College of Chemistry and Molecular Sciences, Wuhan University, Wuhan, 430072, China.
Hybrid artificial layer based on inorganic/polymer composite endows superior toughness and mechanical strength, which can achieve high stability of lithium metal anode. However, the large particle size and uneven distribution of inorganic fillers hinder the uniform flow of lithium ions across the membrane, making it difficult to achieve smooth lithium metal deposition/stripping. In this work, a chemical lithiation-induced defluorination strategy is proposed to engineer poly(vinylidene difluoride) (PVDF)-based artificial layers, enabling in situ incorporation of highly dispersed LiF nanofiller within the polymer matrix and precise control over the LiF content.
View Article and Find Full Text PDFPhys Chem Chem Phys
September 2025
School of Chemistry and Chemical Engineering, Nanjing University of Science and Technology, Nanjing, 210094, China.
To analyse the issues of high muzzle flame intensity and the easy migration of insensitive agents in conventional insensitive propellants, this study synthesizes modified nitrocellulose grafted with carboxymethyl potassium groups by a two-step process, starting from the molecular structure of nitrocellulose (NC), the principal component of propellants. First, the denitration reaction was performed to reduce part of the nitrate ester groups on the surface of NC to hydroxyl groups, followed by an etherification reaction to achieve directional grafting of carboxymethyl potassium groups. Compared with conventional flame retardant/insensitive systems based on nitrogen, phosphorus, or DBP (dibutyl phthalate), potassium-based functional groups exhibit superior thermal stability and environmental friendliness.
View Article and Find Full Text PDFWound Repair Regen
September 2025
Institute of Microsurgery on Extremities, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China.
This study aimed to develop an acellular dermal matrix derived from tilapia skin and evaluate its potential as a bioscaffold for skin wound repair. Structural and compositional changes before and after decellularisation were assessed through histological staining, electron microscopy and immunological analysis. The matrix exhibited low immunogenicity, preserved extracellular matrix architecture and retained key bioactive components.
View Article and Find Full Text PDFCancer Metastasis Rev
September 2025
Institute for Integrative Biology of the Cell (I2BC), Université Paris-Saclay, CEA, CNRS, Gif-Sur-Yvette, 91198, France.
Integrins constitute a large and diverse family of cell adhesion molecules that play essential roles in regulating tumor cell differentiation, migration, proliferation, and neovascularization. Tumor cell-derived exosomes, a subtype of extracellular vesicles, are enriched with integrins that reflect their cells of origin. These exosomal integrins can promote extracellular matrix remodeling, immune suppression, and vascular remodeling and are closely linked to tumor progression and metastasis, acting as pivotal players in mediating organ-specific metastasis.
View Article and Find Full Text PDFEur J Med Chem
September 2025
State Key Laboratory of Natural Medicines and Department of Medicinal Chemistry, School of Pharmacy, China Pharmaceutical University, Nanjing, 211198, PR China. Electronic address:
The Werner syndrome RecQ helicase (WRN) has recently emerged as a novel synthetic lethality target for microsatellite instability-high (MSI-H) cancers. However, available WRN inhibitors or degraders is still lacking so far. Particularly, chemically designed probes capable of degrading WRN irrespective of microsatellite status remain unexplored.
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