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Background: Spinopelvic fixation (SPF) has been a challenge for surgeons despite the advancements in instruments and surgical techniques. C-arm fluoroscopy-guided SPF is a widely used safe technique that utilizes the tear drop view. The tear drop view is an image of the corridor from the posterior superior iliac spine to the anterior inferior iliac spine (AIIS) of the pelvis. This study aimed to define the safe optimal tear drop view using three-dimensional reconstruction of computed tomography images.
Methods: Three-dimensional reconstructions of the pelvises of 20 individuals were carried out. By rotating the reconstructed model, we simulated SPF with a cylinder representing imaginary screw. The safe optimal tear drop view was defined as the one embracing a corridor with the largest diameter with the inferior tear drop line not below the acetabular line and the lateral tear drop line medial to the AIIS. The distance between the lateral border of the tear drop and AIIS was defined as tear drop index (TDI) to estimate the degree of rotation on the plane image. Tear drop ratio (TDR), the ratio of the distance between the tear drop center and the AIIS to TDI, was also devised for more intuitive application of our simulation in a real operation.
Results: All the maximum diameters and lengths were greater than 9 mm and 80 mm, respectively, which are the values of generally used screws for SPF at a TDI of 5 mm and 10 mm in both sexes. The TDRs were 3.40 ± 0.41 and 3.35 ± 0.26 in men and women, respectively, at a TDI of 5 mm. The TDRs were 2.26 ± 0.17 and 2.14 ± 0.12 in men and women, respectively, at a TDI of 10 mm.
Conclusions: The safe optimal tear drop view can be obtained with a TDR of 2.5 to 3 by rounding off the measured values for intuitive application in the actual surgical field.
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http://dx.doi.org/10.4055/cios22360 | DOI Listing |
J Craniofac Surg
September 2025
Department of Anatomy, Faculty of Medicine, Gaziantep University, Gaziantep, Türkiye.
Objective: To reveal differences in morphology of the crista galli (CG) in patients with Chiari malformation type 1 (CMT1) by comparison normal subjects.
Methods: Computed tomography slices of 60 adult CMT1 (gender: 30 females and 30 males, and mean age: 37.20±11.
Bioengineering (Basel)
July 2025
Division of Quantitative Methods and Modeling, Office of Research and Standards, Office of Generic Drugs, Center for Drug Evaluation and Research, U.S. Food and Drug Administration, 10903 New Hampshire Avenue, Silver Spring, MD 20993, USA.
Topical drug administration is a common method of delivering medications to the eye to treat various ocular conditions, including glaucoma, dry eye, and inflammation. Drug efficacy following topical administration, including the drug's distribution within the eye, absorption and elimination rates, and physiological responses can be predicted using physiologically based pharmacokinetic (PBPK) modeling. High-resolution computational models of the eye are desirable to improve simulations of drug delivery; however, these approaches can have long run times.
View Article and Find Full Text PDFInvest Ophthalmol Vis Sci
August 2025
Department of Biomedical Sciences, University of Birmingham, Birmingham, United Kingdom.
Purpose: Wet age-related macular degeneration (AMD) causes vision loss when vascular endothelial growth factor (VEGF) stimulates blood vessel growth into the light-sensitive retina. Anti-VEGF treatments such as ranibizumab are currently administered to treat wet AMD via intravitreal injections, which are unpleasant, expensive, and risk complications. We explored the efficacy of topically administered ranibizumab, with cell-penetrating peptides (CPPs).
View Article and Find Full Text PDFCont Lens Anterior Eye
August 2025
School of Optometry & Vision Science, University of Waterloo, Canada; School of Optometry and Vision Science, Faculty of Medicine and Health, UNSW Sydney, Australia. Electronic address:
Purpose: This study investigated how a contact lens care solution containing a hyaluronic acid derivative (HAD) impacts wettability of rigid lenses, with and without polyethylene glycol (PEG) surface coatings when tested in vitro.
Methods: The adsorption of fluorescently labelled HAD and hyaluronic acid (HA) on to PEG and non-PEG coated lenses was compared by fluorescence quantification. The impact of HAD on sessile drop wettability was investigated on PEG and non-PEG coated lenses, which were cycled 300 times between an artificial tear solution (ATS) for 16 h and 8 h in a HAD or non-HAD containing solution.
Cureus
July 2025
Ophthalmology, School of Medical Sciences and Research, Sharda University, Greater Noida, IND.
Background: Dry eye is a multifactorial ocular surface disorder. While artificial tears and anti-inflammatory medications are standard treatment, blood derivatives such as platelet-rich plasma (PRP) offer regenerative benefits as well and are gaining popularity in ophthalmology. This study aimed at the comparative evaluation of the clinical outcomes of autologous PRP eye drop and artificial tear eye drop (AT) therapy in the treatment of chronic evaporative dry eye patients with moderate to severe symptoms.
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