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Microbial pathogens, including bacteria, fungi and viruses, greatly threaten the global public health. For pathogen infections, early diagnosis and precise treatment are essential to cut the mortality rate. The emergence of aggregation-induced emission (AIE) biomaterials provides an effective and promising tool for the theranostics of pathogen infections. In this review, the recent advances about AIE biomaterials for anti-pathogen theranostics are summarized. With the excellent sensitivity and photostability, AIE biomaterials have been widely applied for precise diagnosis of pathogens. Besides, different types of anti-pathogen methods based on AIE biomaterials will be presented in detail, including chemotherapy and phototherapy. Finally, the existing deficiencies and future development of AIE biomaterials for anti-pathogen applications will be discussed.
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http://dx.doi.org/10.1093/rb/rbad044 | DOI Listing |
Commun Biol
September 2025
Chemical Engineering, IIT, Gandhinagar, Gujarat, India.
Fluorescent molecules are essential for bioimaging and visualizing cellular localization, functionalities, including biosensing, ion sensing, and photochromism. The photocleavable fluorescent protein PhoCl1 belongs to a sub-class of green-to-red photoconvertible β-barrel fluorescent protein and has a characteristic green fluorescence conferred by the chromophore p-HBI. In contrast to other photoconvertible proteins, that shift their fluorescence from green-to-red upon photoexposure, PhoCl1 has been reported to render itself non-fluorescent by releasing the 9 amino-acid C-terminal peptide fragment (CTPF) bearing the photo-transformed red chromophore from the β-barrel.
View Article and Find Full Text PDFNanophotonics
August 2025
Department of Sports Medicine and Rehabilitation, Peking University Shenzhen Hospital, Shenzhen 518036, China.
[This corrects the article DOI: 10.1515/nanoph-2020-0087.].
View Article and Find Full Text PDFChem Rev
September 2025
School of Chemistry, Chemical Engineering and Biotechnology, Nanyang Technological University, 21 Nanyang Link, Singapore 637371, Singapore.
Recent conceptual and technological advances have underlined the importance of the human immune system in responding to dangerous threats, restoring tissue homeostasis, and mounting immunological memory. Our in-depth understanding of the immune system has also been driving the blossoming development of biocompatible macroscale biomaterials designed to prevent and treat various immune-related disorders. Hydrogels, a class of water-swollen networks with extracellular matrix-mimic characteristics, have served as promising biomaterials for guiding the immune system in biological milieus.
View Article and Find Full Text PDFLuminescence
August 2025
Guangdong Key Laboratory of Nanomedicine, CAS-HK Joint Lab of Biomaterials, CAS Key Laboratory of Biomedical Imaging Science and System, Shenzhen Engineering Laboratory of Nanomedicine and Nanoformulations, Shenzhen Key Laboratory of Metabolic Health, Shenzhen Metabolism and Reproductive Targeted De
Highly luminescent nanospheres have been demonstrated to enhance the sensitivity of lateral flow immunoassay (LFIA) due to their loading of numerous luminescent dyes. Herein, aggregation-induced emission (AIE) luminogens (AIEgens)-embedded nanospheres (AIENPs) with red-emissive AIE-active europium complexes were developed as signal amplification probes for LFIA for rapid and point-of-care detection of COVID-19 biomarkers, nasopharyngeal carcinoma biomarkers, and methamphetamine. Compared with the colloidal gold-based rapid and point-of-care detection approach, the AIENPs-based approach showed more than 10 times sensitivity to the target proteins and small molecules, highlighting its significant potential for pathogen- or cancer-related diseases early detection and screening, as well as its applicability in public safety monitoring.
View Article and Find Full Text PDFBiomacromolecules
September 2025
Department of Plastic Surgery, The Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430014, China.
The development of durable, light-activated antibacterial materials is crucial for addressing microbial contamination in biomedical and textile applications. Herein, we report the fabrication of photoresponsive antibacterial cellulose fibers by doping a Type I aggregation-induced emission (AIE) photosensitizer, PS 1, via a wet-spinning strategy. PS 1 exhibits strong fluorescence and efficient reactive oxygen species (ROS) generation in the aggregated state, primarily producing superoxide anions with minimal singlet oxygen.
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