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http://dx.doi.org/10.1097/SLA.0000000000005931 | DOI Listing |
BMJ Med
September 2025
Department of Prescription Data, Central Research Institute of Ambulatory Health Care, Berlin, Germany.
Objectives: To identify and quantify prescriptions after a covid-19 infection compared with other acute respiratory infections in previously healthy patients and those with chronic disease.
Design: Comparative observational study based on German routine data.
Setting: Ambulatory care of all residents in Germany with statutory health insurance (88% of the German population).
World J Urol
September 2025
Sindh Medical College, Jinnah Sindh Medical University, Karachi, Sindh, Pakistan.
J Geriatr Cardiol
August 2025
Interventional Cardiology, Sandro Pertini Hospital, Rome, Italy.
Background: Antithrombotic strategies after percutaneous coronary interventions (PCI) in elderly patients on oral anticoagulant therapy (OAT) are debated due to the balance between ischemic and bleeding risks. Recent guidelines recommend early transitioning from triple antithrombotic therapy to dual antithrombotic therapy, but there are limited data on elderly patients.
Methods: We performed a age-specific analysis of the PERSEO Registry population aimed to compare clinical features, therapeutic strategies, and outcomes of individuals aged ≥ 80 years and < 80 years who were on OAT and underwent PCI with stent.
J Enzyme Inhib Med Chem
December 2025
School of Life Sciences, Jinggangshan University, Ji'an, China.
Current antithrombotic therapies face dual constraints of bleeding complications and monitoring requirements. Although natural hirudin provides targeted thrombin inhibition, its clinical adoption is hindered by sourcing limitations. This study developed a recombinant hirudin variant HMg (rHMg) with enhanced anticoagulant activity through genetic engineering and established cost-effective large-scale production methods.
View Article and Find Full Text PDFJ Diabetes
September 2025
Department of Cardiology, Zhongshan Hospital, Fudan University, Shanghai Institute of Cardiovascular Diseases, National Clinical Research Center for Interventional Medicine, Shanghai, China.
Background: Despite increased risk of ischemic events in diabetes, the optimal anti-thrombotic strategy for secondary prevention has not been defined. We aimed to assess the efficacy and safety of optimal antiplatelet agents such as indobufen-based dual antiplatelet therapy (DAPT) in patients with diabetes after coronary stenting.
Methods: OPTION trial was a randomized, open-label, noninferiority, and multicentric study in China.