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Purpose: The primary aim of this study is to determine the influence of an intervention in women based on a free mobile application (LactApp, Barcelona, Spain) in maintaining breastfeeding (BF) up to 6 months postpartum. The secondary aim is to assess the effect of health literacy (HL) on breastfeeding duration.
Methods: A multicenter, randomized controlled clinical trial of parallel groups will be carried out. Women will be randomly assigned to each of the parallel groups. In the control group, usual clinical practice will be followed from the third trimester of pregnancy to promote BF. In the intervention group, and in addition to usual clinical practice, the women will use a free mobile application (LactApp) from the third trimester to 6 months postpartum. The type of BF at birth, at 15 days and at 3 and 6 months postpartum and the causes of cessation of BF in both groups will be monitored. The hypothesis will be tested using inferential analysis, considering an alpha of 5%. The study protocol was approved by the Clinical Research Ethics Committee of Hospital de la Ribera (Alzira, Valencia, Spain) in February 2021. A per protocol analysis and an intention-to-treat analysis will be performed.
Discussion: This study will identify the influence of a mobile application on improving BF rates. If the application proves effective, we will have a tool with free information available to any user at any time of day, which may be complemented by normal clinical practice and be integrated into our health care system.
Trial Registration: ClinicalTrials.gov ID: NCT05432700.
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http://dx.doi.org/10.3390/healthcare11101434 | DOI Listing |
Acta Psychol (Amst)
September 2025
University Sains Malaysia, 11800, Penang, Malaysia; Berlin School of Business and Innovation (BSBI), Berlin, Germany. Electronic address:
This study examines the impact of AI-enhanced transformational leadership on IT professional burnout among Chinese IT professionals while investigating the mediating role of AI learning self-efficacy and the moderating effects of AI-enabled work practices and organizational AI-communication adequacy. Drawing on the technology-organization-environment (TOE) Framework, our research integrates traditional transformational leadership with emerging AI applications, offering a comprehensive model for understanding how digital leadership influences employee well-being in high-pressure IT environments. Data collected from 511 IT professionals across major Chinese technology hubs were analyzed using SMART-PLS.
View Article and Find Full Text PDFBrief Bioinform
September 2025
Department of Computer Science, Hanyang University, 222 Wangsimni-ro, Seoul 04763, Republic of Korea.
Motivation: Mobile genetic elements (MGEs) play an important role in facilitating the acquisition of antibiotic resistance genes (ARGs) within microbial communities, significantly impacting the evolution of antibiotic resistance. Understanding the mechanism and trajectory of ARG acquisition requires a comprehensive analysis of the ARG-carrying mobilome-a collective set of MGEs carrying ARGs. However, identifying the mobilome within complex microbiomes poses considerable challenges.
View Article and Find Full Text PDFContraception
September 2025
Bayer Aktiengesellschaft, Wuppertal - Aprath, Germany.
Objective: This study aimed to validate the real-world performance of the MyIUS mobile-application algorithm in predicting bleeding intensity and regularity in levonorgestrel intrauterine device (LNG-IUD) 52 mg, 19.5 mg, and 13.5 mg users following device insertion.
View Article and Find Full Text PDFJ Hazard Mater
August 2025
School of Resources and Environment, Northeast Agricultural University, Harbin 150030, PR China. Electronic address:
Residues of veterinary antibiotics such as tylosin in soils can induce selective pressure on indigenous soil microbes and increase the dissemination risk of antibiotic resistance genes (ARGs) by horizontal gene transfer (HGT), which poses a serious threat to both soil and public health. While conventional bioremediation methods face challenges in efficiency and stability, enzyme-based approaches offer promising alternatives. This study developed a novel biochar-immobilized tylosin-degrading enzyme (BIE) system to simultaneously address tylosin contamination and antibiotic resistance gene (ARG) proliferation in agricultural soils.
View Article and Find Full Text PDFHead Neck
September 2025
Department of Oral Oncology, Hiroshima University Graduate School of Biomedical and Health Sciences, Hiroshima, Japan.
Background: Reconstruction of head and neck mucosal defects presents unique challenges due to the anatomical complexity and functional demands of the region. Artificial biomaterials such as collagen and polyglycolic acid (PGA) sheets have gained clinical traction owing to their ease of use and reduced surgical burden. However, limitations such as local inflammation, degradation-related complications, and mechanical instability-particularly in highly mobile areas like the tongue-continue to hinder their broader application.
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