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Vonoprazan (VPZ) inhibits gastric acid secretion more potently than proton pump inhibitors. Recently, attention has been focused on the dual therapy with VPZ and amoxicillin (AMOX) for the eradication of The dual VPZ/AMOX therapy attains the sufficient eradication rate with lowering the risk of adverse events in comparison with the triple therapy and quadruple therapy. Therefore, the dual VPZ/AMOX therapy is considered a useful eradication regimen for infection.
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http://dx.doi.org/10.3390/jcm12093110 | DOI Listing |
Rev Med Liege
September 2025
Service de Diabétologie, Nutrition et Maladies métaboliques, CHU Liège, Belgique.
Tirzepatide is a unimolecular dual agonist of both glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP) receptors, recently commercialized and reimbursed in Belgium for the treatment of type 2 diabetes (T2D). Because of the complementarity of action of the two incretins, tirzepatide showed, in a dose-dependent manner (5, 10 and 15 mg as a once-weekly subcutaneous injection), a better efficacy (greater reduction in HbA1c and body weight) compared with placebo, semaglutide 1 mg, basal insulin and preprandial boluses of insulin lispro in six studies of the SURPASS programme. Tirzepatide tolerance is almost similar to that of pure GLP-1 receptor agonists, with digestive adverse events, most often during the first weeks after initiation, which justifies the recommendation of progressive titration every four weeks.
View Article and Find Full Text PDFAdv Healthc Mater
September 2025
Hebei Key Laboratory of Biomaterials and Smart Theranostics, School of Health Sciences and Biomedical Engineering, Hebei University of Technology, Tianjin, 300131, China.
Periprosthetic joint infection (PJI) represents a serious complication following joint arthroplasty, and it often results in implant failure, prolonged morbidity, and additional healthcare burdens. Current clinical strategies for PJI treatment face obstacles, including antibiotic resistance, high recurrence rate, and compromised bone repair. To address these challenges, a novel nanozyme-based coordination compound designated as W-GA-Van@Zn is developed.
View Article and Find Full Text PDFACS Appl Mater Interfaces
September 2025
State Key Laboratory of Cardiovascular Diseases and Medical Innovation Center, Shanghai East Hospital, School of Medicine, Tongji University, Shanghai 200070, China.
Wound infections challenge clinical medicine, and developing novel therapies is critically important in overcoming antimicrobial resistance and an off-balanced immune microenvironment. Electrical stimulation as a biocompatible, easy-to-operate, and controllable technique has great potential in eradicating pathogens and modulating the immune system. However, safe and soft platforms that integrate both bactericidal and immunological modulatory effects of electrical stimulation are rarely reported.
View Article and Find Full Text PDFKidney Blood Press Res
August 2025
Primary hyperoxaluria type 1 (PH1) is a rare autosomal recessive disorder caused by a deficiency of the hepatic peroxisomal enzyme alanine-glyoxylate aminotransferase (AGT), which catalyses the conversion of glyoxylate to glycine, resulting in increased oxalate production. The clinical consequences of the progressive build up of oxalates include nephrocalcinosis, nephrolithiasis, chronic kidney disease and ultimately renal failure with extra-renal involvement. The diagnosis of PH1 is challenging due to the non-specific nature of its symptoms and the need for costly genetic testing.
View Article and Find Full Text PDFACS Appl Mater Interfaces
September 2025
Institute of Colloid and Biointerface Science, Institute of Colloid and Biointerface Science, BOKU University, 1190 Vienna, Austria.
Implant-associated infections caused by bacterial biofilms remain a major clinical challenge, with high morbidity, often necessitating prolonged antibiotic therapy or implant revision surgery. To address the need for noninvasive alternatives, we investigated the use of alternating magnetic fields (AMFs) as a localized treatment modality for eradicating biofilms on titanium implant model surfaces. We demonstrate that AMF exposure effectively removes biofilms and kills bacteria at moderately elevated temperatures on the implant.
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