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http://dx.doi.org/10.1097/ALN.0000000000004569 | DOI Listing |
Sci Rep
August 2025
Department of Pharmacy, West China Second University Hospital, Sichuan University, Chengdu, 610041, China.
The Chinese Expert Consensus on central precocious puberty (CPP) defines girls' rapid sexual development before age 8 as CPP; while after age 8 as early normal puberty (ENP). And the use of recombinant human growth hormone (rhGH) for CPP and ENP is off-label and lacks reliable evidence for clinical practice. This study only included girls due to the low prevalence among boys.
View Article and Find Full Text PDFSpine (Phila Pa 1976)
August 2025
Dept. of Spine Surgery, Hospital for Special Surgery, New York, NY.
Study Design: Retrospective review of electronic health records system.
Objective: To compare the indications and complication rates between rhBMP-2 and non-rhBMP-2 use in spine fusion at a high-volume tertiary orthopedic institution.
Summary Of Background Data: Bone morphogenetic proteins are growth factors that play a critical role in bone development and proliferation.
BMC Ophthalmol
August 2025
Vista Augenklinik Binningen, Hauptstrasse 55, Binningen, 4102, Switzerland.
Background: Anti-vascular endothelial growth factor (VEGF) intravitreal injection treatment (IVT)s are gold standard for various neovascular retinal diseases, including neovascular age-related macular degeneration (nAMD), diabetic macular edema (DME), and macular edema due to retinal vein occlusion (RVO). Same day bilateral IVTs are commonly performed off-label worldwide to reduce patient burden, despite limited safety data. This study evaluates the safety and management of bilateral same day anti-VEGF injections within a treat-and-extend regimen (TER) and proposes a clinical guideline for coordination of bilateral treatment.
View Article and Find Full Text PDFJ Cardiothorac Vasc Anesth
July 2025
Department of Anesthesiology, Division of Critical Care, University of Kansas Medical Center, Kansas City, KS; University of Kansas Medical Center, Kansas City, KS.
Objectives: Activated recombinant factor VII (rFVIIa) has been used to treat cardiac surgical bleeding in an off-label manner. Due to the high risk of mortality with ongoing hemorrhage, assessing the risk of potential thrombotic effects of rFVIIa administration is important. This report analyzes the characteristics associated with mortality in patients who received very-low-dose rFVIIa for nonsurgical bleeding.
View Article and Find Full Text PDFAnat Sci Int
August 2025
Department of Neuroanatomy, Juntendo University Graduate School of Medicine, Tokyo, Japan.
Adeno-associated virus (AAV) vectors are widely used to label individual neurons by expressing fluorescent proteins. To analyze neuronal morphology in detail, it is important to achieve sparse and strong expression of fluorescent proteins for clearly visualizing cell bodies, dendrites, and axons. However, injections of high-titer AAV vectors often result in excessive cell labeling, while injecting low-titer AAV vectors reduces signal intensity.
View Article and Find Full Text PDF