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Background/aim: This study compared two types of parallel-plate ionization chamber to clarify the pitfalls of dosimetry in electron radiation therapy.
Materials And Methods: The ion recombination correction factor and polarity effect correction factor, sensitivity, and percentage depth doses (PDDs) of PPC05 and PPC40 parallel-plate ionization chambers were compared in a small-field electron beam. The output ratios were measured for 4-20 MeV electron beams with field sizes of 10 cm × 10 cm, 6 cm × 6 cm, and 4 cm × 4 cm. Furthermore, the films were placed in water and positioned in the beam with their surface perpendicular to the beam axis, and lateral profiles were obtained for each beam energy and each field.
Results: Regarding PDDs, at depths greater than the peak dose, the percentage depth dose for PPC40 was smaller than that for PPC05 in small fields and at beam energies greater than 12 MeV, which could be attributed to the lack of lateral electron equilibrium at small depths and multiple scattering events at large depths. The output ratio of PPC40 was approximately 0.025-0.038, which was lower than that of PPC05 in a 4 cm × 4 cm field. For large fields, the lateral profiles were similar, regardless of the beam energy, however, for small fields, the flatness of the lateral profile was beam energy dependent.
Conclusion: The PPC05 chamber, which has a smaller ionization volume, is therefore more suitable than the PPC40 chamber for small-field electron dosimetry, in particular at high beam energies.
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http://dx.doi.org/10.21873/anticanres.16356 | DOI Listing |
Med Phys
July 2025
Department of Radiation Oncology, Washington University School of Medicine, St. Louis, Missouri, USA.
Background: Proton GRID radiotherapy (RT) is an extension of photon spatially fractionated radiation therapy (SFRT) techniques for bulky invasive tumors. It has been hypothesized that GRID RT improves the therapeutic ratio by minimizing normal tissue toxicities associated with treating bulky volumes while inducing abscopal radiobiologic effects. However, compact, synchrocyclotron-based proton therapy machines with large spot sizes pose unique technical challenges in implementing proton GRID RT.
View Article and Find Full Text PDFPhys Med Biol
July 2025
Department of Radiation Oncology Physics & Technology, Cancer Hospital of Shandong First Medical University, Jinan, People's Republic of China.
To experimentally determine beam quality correction factors () for six cylindrical and four parallel-plate ionization chambers (ICs) in both spread-out Bragg peak (SOBP) and single-layer proton beam configurations.Water calorimetry was implemented to establish absorbed dose to water () at 10 g cmdepth for SOBP and single-layer proton beams. IC measurements were performed under identical geometrical conditions as calorimetric measurements, with the exception of water temperature control in the phantom.
View Article and Find Full Text PDFAppl Radiat Isot
November 2025
Instituto de Pesquisas Energéticas e Nucleares (IPEN-CNEN), Comissão Nacional de Energia Nuclear, Av. Prof. Lineu Prestes 2242, 05508-000, São Paulo, SP, Brazil.
The aim of this work was to verify the possibility of the application of a special parallel-plate ionization chamber, developed at the Calibration Laboratory (IPEN), for mammography dosimetry. The homemade chamber has a polymethyl methacrylate body, 10 cm of sensitive length, and a sensitive volume of 3.2 cm.
View Article and Find Full Text PDFZ Med Phys
May 2025
Division of Medical Physics, Department of Radiation Oncology, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, German Cancer Consortium (DKTK), partner site DKTK, Freiburg, Germany.
Purpose: This study presents an in-house developed set-up enabling the placement of multiple TLDs over the target region, for in vivo dosimetry in intraoperative electron beam radiotherapy (IOERT).
Methods And Materials: TLD-100 (LiF:MgTi) rods were calibrated at 10 Gy and their response was determined for the nominal electron energies of the Mobetron LINAC within the dose range from 4 Gy to 20 Gy. Irradiation of various set-ups was performed using the ionisation chambers (IC) ROOS parallel plate 34001 (PTW, Freiburg) and 3D Semiflex 31021 (PTW, Freiburg), a microdiamond detector 60019 (PTW, Freiburg) and EBT3 films (Ashland™) to investigate beam perturbations that may result due to the structure of the set up.
Med Phys
June 2025
Departamento de Física de Partículas, Universidade de Santiago de Compostela, Santiago de Compostela, A Coruña, Spain.
Background: Air-vented ionization chambers exposed to clinical radiation beams may suffer from recombination during the drift of the charge carriers towards the electrodes. Thus, dosimetry protocols recommend the use of a correction factor, usually denominated saturation factor ( ), to correct the ionization chamber readout for the incomplete collection of charge. The two-voltage method (TVM) is the recommended methodology for the calculation of the saturation factor, however, it is based on the early Boag model, which only takes into account the presence of positive and negative ions in the ionization chamber and does not account for the electric field screening or the free electron contribution to the signal.
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