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Article Abstract
Background: Colorectal cancer is the third most common malignant tumor in the world and substantial death cases are reported each year. We aimed to explore the molecular mechanism underlying colorectal cancer tumor-igenesis and progression.
Methods: The expression levels of () in colorectal cancer tissues were first analyzed using Gene Expression Profiling Interactive Analysis (GEPIA). More multiple in vitro experiments established the role of in colorectal cancer progression. The potential downstream target of was identified by Western blot analysis.
Results: FOXA2 expression level was significantly up-modulated in colorectal cancer specimens and cells (<0.05). Silencing remarkably inhibited colorectal cancer cells growth, invasion and migration. BCL2-associated X (BAX) protein was identified as a potential downstream protein of .
Conclusion: Our findings demonstrated the essential role of in colorectal cancer progression and identified BAX protein as its potential target.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10113591 | PMC |
| http://dx.doi.org/10.18502/ijph.v52i2.11883 | DOI Listing |
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