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Article Abstract
Herein we report the design and synthesis of a terphen[]arene derivative functionalised with sulfate acid ester groups. This water-soluble terphen[3]arene host effectively encapsulates a multitude of neuromuscular blocking agents (NMBAs) with high affinity, showing great potential as a NMBAs reversal agent in pharmaceutical research.
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Water-soluble terphen[3]arene macrocycle: a versatile reversal agent of neuromuscular blockers.
Chem Commun (Camb)
May 2023
Tianjin Key Laboratory of Structure and Performance for Functional Molecules, College of Chemistry, Tianjin Normal University, Tianjin 300387, P. R. China.
Article Synopsis
- The study presents a new terphen[3]arene compound modified with sulfate acid ester groups, making it soluble in water.
- This compound has the ability to effectively encapsulate various neuromuscular blocking agents (NMBAs) with strong binding affinity.
- The findings suggest that this terphen[3]arene derivative could be a promising candidate for reversing the effects of NMBAs in pharmaceutical applications.
The effective taste masking of alkaloids by a water-soluble terphen[3]arene.
Chem Commun (Camb)
March 2022
Key Laboratory of Inorganic-Organic Hybrid Functional Material Chemistry, Ministry of Education, Tianjin Key Laboratory of Structure and Performance for Functional Molecules, College of Chemistry, Tianjin Normal University, Tianjin 300387, P. R. China.
The synthesis of the first water-soluble 2,2'',4,4''-terphen[3]arene bearing sulphonatopropoxy moieties (STP3) and its effective alleviation of aversive responses to alkaloids and , the formation of supramolecular complexes, have been described. Using such direct host-guest complexation, STP3 has potential applications as an efficient taste-masking macrocyclic container for use in pharmaceutical research.
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