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http://dx.doi.org/10.3389/fgene.2023.1119967 | DOI Listing |
Front Microbiol
August 2025
Department of Epidemiology and Ecology of Antimicrobial Resistance, Helmholtz Institute for One Health, Helmholtz Centre for Infection Research HZI, Greifswald, Germany.
Introduction: The (KP) species complex (KpSC) comprises KP as the predominant species, and six other taxa including two subspecies each of var (KV) and (KQ), all capable of causing clinical infections and often challenging to differentiate. Among these, KP is by far the most clinically significant, with the emergence of multidrug-resistant and hypervirulent strains leading to severe infections and limited treatment options, underscoring the need to understand the genomic features of KP.
Methods: This study compared globally disseminated KP lineages with less abundant KV strains in synthetic human urine (SHU) across multiple omics levels to identify characteristics differentiating these closely related species.
Front Cell Infect Microbiol
September 2025
Fundació Lluita contra les Infeccions, Badalona, Spain.
Background: The intestinal microbiota composition has been linked to neurocognitive impairment in people with HIV (PWH). However, the potential interplay of microbial species and related metabolites, particularly in the context of an HIV cure strategy remains underexplored. The BCN02 trial evaluated the impact of romidepsin (RMD), used as a HIV-1 latency reversing agent and with reported beneficial neurological effects, combined with the MVA.
View Article and Find Full Text PDFFront Immunol
September 2025
Department of Endocrinology and Metabolism, The Eighth Affiliated Hospital of Southern Medical University (The First People's Hospital of Shunde Foshan), Foshan, Guangdong, China.
Background: Oxidative stress is a key contributor to the pathogenesis of the autoimmune condition thyroid eye disease (TED). However, its precise molecular mechanisms and reliable biomarkers remain unclear. Bioinformatics enables the identification of differentially expressed genes through transcriptomic analysis.
View Article and Find Full Text PDFFront Vet Sci
August 2025
Tranditional Chinese Veterinary Medicine Laboratory, College of Veterinary Medicine, Gansu Agricultural University, Lanzhou, China.
Background: This study addresses the global challenge of subclinical bovine mastitis (SCBM) in dairy cows, a prevalent disease causing substantial economic losses, by investigating the mechanistic basis of , a traditional herbal remedy with empirically validated efficacy but incompletely understood modes of action.
Methods: Initially, the active components of were identified using LC-MS/MS. Dose-response trials were conducted in Holstein cows ( = 24 SCBM cases; = 6 healthy controls), along with multi-omics integration, including 16S rRNA sequencing for rumen/feces microbiota and UHPLC-MS metabolomics for serum analysis.
Front Cell Infect Microbiol
August 2025
State Key Laboratory for Diagnosis and Treatment of Severe Zoonotic Infectious Diseases, Institute of Zoonosis, College of Veterinary Medicine, Jilin University, Changchun, China.