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Article Abstract
Introduction: Upon infection, insect hosts simultaneously express a cocktail of antimicrobial peptides (AMPs) which can impede pathogen colonization and increase host fitness. It has been proposed that such a cocktail might be adaptive if the effects of co-expressed AMPs are greater than the sum of individual activities. This could potentially prevent the evolution of bacterial resistance. However, studies on AMPs in combination are scarce. Attacins are one of the relatively large AMP families, which show anti-Gram-negative activity .
Material And Methods: Here, we used RNA interference (RNAi) to silence three members of the Attacin family genes in the mealworm beetle, : ( (), (), and 2 () both individually and in combination. We then infected with the Gram negative entomopathogen .
Results: We found that survival of the beetles was only affected by the knockdown of , and the knockdown of all three Attacins together. Triple knockdown, rather than individual or double knockdowns of AMPs, changes the temporal dynamics of their efficiency in controlling the colonization of in the insect body.
Discussion: More precisely, AMP gene expression influences load early in the infection process, resulting in differences in host survival. Our results highlight the importance of studying AMP-interactions .
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10090678 | PMC |
| http://dx.doi.org/10.3389/fimmu.2023.1140627 | DOI Listing |
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