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Objective: To describe the application and early outcome of a custom-made unipolar partial tarsal replacement in a dog with an extensive medial talar ridge OCD.
Animal: A 7-month-old, 25 kg male Rhodesian Ridgeback with progressive left hindlimb lameness (grade III-IV/IV) and diagnosis of talar OCD.
Methods: The dog presented with progressive lameness attributed to extensive medial talar ridge OCD. Due to the severity of the lesion, a resurfacing procedure was chosen. Based on CT data, a bi-layered resurfacing implant consisting of a titanium socket and a polycarbonate urethane bearing surface was constructed. For intraoperative guidance, a set of matching drill guides were 3D-printed, along with some models of the affected talus, to allow for dry-lab training. Surgical implantation using a medial malleolar osteotomy to approach the lesion was without complications. Orthopedic follow-up examinations were conducted at 10 days, 4 weeks, 6 weeks, 6 months and 12 months. Radiographic examinations were included at the 6-week, 6-month, and 12-month follow-ups.
Results: Function improved considerably during the follow-up period with a lameness grade of 0-I/IV at the 12-month follow-up. ROM differed by 15° in flexion compared to the contralateral side, while there was no difference in extension. Moderate periarticular fibrosis was present at 12 months. Implant positioning was unchanged at follow-up-radiographic examination and there was only mild progression of osteoarthritis (OA).
Conclusion: Patient specific instrumentation - guided tarsal OCD resurfacing with a synthetic patient-specific implant may be an effective treatment option.
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http://dx.doi.org/10.1111/vsu.13954 | DOI Listing |
J Eval Clin Pract
September 2025
Department of General Medicine, Osaka Medical and Pharmaceutical University Hospital, Takatsuki, Osaka, Japan.
Rationale: Physicians sometimes encounter various types of gut feelings (GFs) during clinical diagnosis. The type of GF addressed in this paper refers to the intuitive sense that the generated hypothesis might be incorrect. An appropriate diagnosis cannot be obtained unless these GFs are articulated and inventive solutions are devised.
View Article and Find Full Text PDFJ Eval Clin Pract
September 2025
Cochrane Taiwan, Taipei Medical University, Taipei, Taiwan.
Background: Chest radiography is often performed preoperatively as a common diagnostic tool. However, chest radiography carries the risk of radiation exposure. Given the uncertainty surrounding the utility of preoperative chest radiographs, physicians require systematically developed recommendations.
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September 2025
Department of Biochemistry, Faculty of Pharmacy, Cairo University, Cairo, Egypt.
Background: Prostate cancer is one of the most common malignancies in males worldwide. Serum prostate-specific antigen is a frequently employed biomarker in the diagnosis and risk stratification of prostate cancer; however, it is known for its low predictive accuracy for disease progression. New prognostic biomarkers are needed to distinguish aggressive prostate cancer from low-risk disease.
View Article and Find Full Text PDFSex Reprod Health Matters
September 2025
Senior Research Scientist, Guttmacher Institute, New York, United States.
Since the release of the Supreme Court decision in June 2022, researchers have been working to better understand the impact that the growing number of abortion restrictions are having on the provision of and access to abortion services in the United States (US). Less is known about the impact of abortion restrictions on the provision of sexual and reproductive health (SRH) services more broadly, including at clinics that do not directly offer abortion. Between November 2023 and February 2024, we conducted interviews with SRH managers, clinic managers, and other administrators at publicly funded SRH clinics around the US to generate evidence on the effects of state-level abortion restrictions on the provision of abortion and related services, such as pregnancy options counselling and abortion referrals, at facilities providing contraceptive services.
View Article and Find Full Text PDFZhong Nan Da Xue Xue Bao Yi Xue Ban
May 2025
Department of Geriatric Pulmonary and Critical Care Medicine, Xiangya Hospital, Central South University; National Clinical Research Center for Geriatric Disorders (Xiangya Hospital), Changsha 410008.
Objectives: Non-small cell lung cancer (NSCLC) is associated with poor prognosis, with 30% of patients diagnosed at an advanced stage. Mutations in the and genes are important prognostic factors for NSCLC, and targeted therapies can significantly improve survival in these patients. Although tissue biopsy remains the gold standard for detecting gene mutations, it has limitations, including invasiveness, sampling errors due to tumor heterogeneity, and poor reproducibility.
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