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Aroma compounds play a key role in wine quality due to their importance in wine aroma. The aim of the present study is to investigate the influence of cold pre-fermentative maceration (CPM) treatment on aromatic and sensory properties of white wines from four grape varieties (Tempranillo Blanco, Maturana Blanca, Viura and Garnacha Blanca) during two consecutive years (2019 and 2020). A total of 62 aroma compounds belonging to different chemical families were identified using headspace solid-phase microextraction combined with gas chromatography mass spectrometry (HS-SPME/GC-MS). CPM treatment enhanced the total relative concentration of alcohols, esters and acids compared to control wines. Regarding sensorial properties, esters made the greatest contribution to the studied white wines, mainly through the development of floral and fruity notes. On the other hand, CPM treatment did not significantly influence the total relative concentration of terpenoids, and different trends were observed according to grape variety and vintage. The obtained results showed differences in the wine's aromatic complexity according to the grape variety, the vintage and the treatment applied and suggested that CPM treatment could represent a suitable approach to manipulate the aromatic profile and enhance the aromatic quality and complexity of wine.
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http://dx.doi.org/10.3390/foods12061135 | DOI Listing |
J Manipulative Physiol Ther
September 2025
Department of Physical Education, Federal University of Sergipe, Cidade Universitária Professor José Aloísio de Campos, São Cristóvão, Sergipe, Brazil.
Objective: The purpose of this study was to compare the effects of 16 weeks of functional versus dual-task training on aspects of pain in older women with chronic nonspecific low back pain.
Methods: This randomized clinical trial included 38 participants aged 60 to 79 years divided into 2 groups: functional training (FT) and dual-task training (DT). We assessed pressure pain threshold (PPT), temporal summation of pain, conditioned pain modulation (CPM), trunk instability, isometric strength, and endurance of trunk muscles before and 16 weeks after training.
JDR Clin Trans Res
September 2025
Division of Oral and Maxillofacial Surgery, Faculty of Dentistry, The University of Hong Kong, Hong Kong SAR, China.
Background: This systematic review aims to analyze the effectiveness of the combination of herbal medicine and corticosteroids in oral lichen planus (OLP) management. By providing an updated insight into the medicinal properties of this combined treatment approach, the review seeks to address the current gap in the understanding of its therapeutic potential for this chronic premalignant disorder.
Materials And Methods: PubMed, Web of Science, Scopus, Cochrane Library, CNKI, and WanFang databases were searched to identify randomized controlled trials comparing Chinese patent medicine (CPM) with corticosteroids and corticosteroids alone in treating OLP.
bioRxiv
August 2025
Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, USA.
Translocation renal cell carcinoma (tRCC) is an aggressive kidney cancer driven by gene fusions of the transcription factor. is essential in tRCC but dispensable in normal cells, presenting an attractive but pharmacologically challenging therapeutic target. We show that the basic helix-loop-helix (bHLH) domain of TFE3 is crucial for chromatin binding and transcriptional function.
View Article and Find Full Text PDFAm J Phys Med Rehabil
September 2025
Ghent University, Department of Rehabilitation Sciences. Corneel Heymanslaan 10, Ghent, Belgium.
The interest in dry needling as a treatment option for myofascial pain has flourished for the last decades and will probably continue to do so, since multiple clinical effects can be attributed to this technique. However, evidence about the underlying physiological mechanisms of its effects is still underrepresented in scientific research and caution must be taken in generalizing results from acupuncture or animal research. This review offers an overview of the possible mechanisms involved in the pathophysiology of myofascial trigger points, i.
View Article and Find Full Text PDFJ Taibah Univ Med Sci
August 2025
Department of Chemistry, College of Science, King Faisal University, Al-Ahsa 31982, KSA.
Objective: This study assessed the antimicrobial efficacy of photodynamic therapy (PDT) using functionalized graphene oxide with methylene blue (MB/rGO) to achieve root canal disinfection against .
Methods: In this in vitro study, biofilms were developed on 105 single-rooted teeth after decoronation over 21 days. Bacterial viability was assessed with colony forming unit (CFU) analysis.