Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
Purpose: This study aimed to compare the efficacy of topical bevacizumab and motesanib in an experimental corneal neovascularization model, and find the most effective motesanib dose.
Materials And Methods: In experiments, 42 Wistar Albino rats were randomly divided into six groups (n = 7). Corneal cauterization was applied to all groups except the group 1. Group 1 did not receive any treatment. Topical dimethylsulfoxide was applied to sham group three times a day(tid). Topical bevacizumab drops (5 mg/ml) were applied to Group 3 tid. Topical motesanib drops with a dose of 2.5, 5, and 7.5 mg/ml were respectively applied in Groups 4, 5, and 6 tid. On the 8th day, corneal photographs of all rats were taken under general anesthesia, and the percentage of corneal neovascular area was calculated. VEGF-A mRNA, VEGFR-2 mRNA, miRNA-21, miRNA-27a, miRNA-31, miRNA-126, miRNA-184, and miRNA-204 were evaluated by the qRT-PCR method in corneas taken after decapitation.
Results: The percentage of corneal neovascularization areas and VEGF-A mRNA expression levels were decreased in all treatment groups compared to group 2 (p < 0.05). VEGFR-2 mRNA levels were found to be statistically significantly decreased in groups 4 and 6 compared to group 2 (p < 0.05). Statistically significant changes were detected in the expression levels of only miRNA-126 among all miRNAs.
Conclusion: Motesanib with a dose of 7.5 mg/ml statistically significantly suppressed the VEGFR-2 mRNA level compared with other treatment doses and may be more effective than bevacizumab. Further, miRNA-126 can be used as a proangiogenic marker.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1007/s10792-023-02685-3 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
[Use of ozone therapy in the treatment of complications following penetrating keratoplasty for rosacea-associated keratitis].
Vestn Oftalmol
September 2025
Chelyabinsk Regional Clinical Hospital, Chelyabinsk, Russia.
Rosacea is a chronic inflammatory dermatosis, one manifestation of which involves pathological processes in various ocular structures. The most severe form is rosacea-associated keratitis. Given the multifactorial etiology and pathogenesis, this condition remains unpredictable and resistant to treatment.
View Article and Find Full Text PDFOcular toxicity and potential mechanism of nanomaterials: An issue worthy of investigation.
Ecotoxicol Environ Saf
September 2025
Department of Orthordontics, School and Hospital of Stomatology, Guangdong Engineering Research Center of Oral Restoration and Reconstruction & Guangzhou Key Laboratory of Basic and Applied Research of Oral Regenerative Medicine, Guangzhou Medical University, Guangzhou, China. Electronic address: 20
Nanomaterials are widely used. The gases emitted from industrial manufacturing contain nanoparticles, which increases the chance of nanomaterials coming into contact with the eyes. Nanomaterials may cause damage to the eyeball wall and eye contents, manifested as keratitis, neovascularization of the iris, vitreous inflammation, retinitis, etc.
View Article and Find Full Text PDFInjectable High-Adhesion Fibrinogen-Silk Fibroin Hydrogel Loaded with Curcumin Accelerates Pterygium Repair via Dual Anti-Inflammatory/Antiproliferative Mechanisms.
ACS Appl Mater Interfaces
September 2025
Department of Ophthalmology, Nanjing Drum Tower Hospital Clinical College of Nanjing University of Chinese Medicine, 321 Zhongshan Road, Nanjing 210008, China.
Pterygium is a common ocular surface lesion, and postoperative recurrence remains a major challenge due to insufficient therapeutic strategies targeting fibroblast proliferation and inflammation. Fibrinogen hydrogel (Fibrin glue, FG), a bioadhesive hydrogel, is widely used in pterygium surgery to secure conjunctival autografts. However, its low adhesion often leads to graft detachment, hindering effective repair.
View Article and Find Full Text PDFFrom tumor microenvironment to ocular hypertension: unraveling the pathogenesis and therapeutic strategies of cancer-related glaucoma.
Front Med (Lausanne)
August 2025
Xiamen Eye Center and Eye Institute of Xiamen University, School of Medicine, Xiamen, China.
Cancer is a global health threat, and its incidence and mortality are increasing annually. Cancer-related glaucoma, a severe complication caused by primary or metastatic tumors and their treatments, has complex pathogenic mechanisms. This review aims to clarify the risk factors, classification, diagnosis, and treatment progress of this glaucoma type.
View Article and Find Full Text PDFThe effect of limbal tissue with conjunctival flap and bovine amniotic membrane on alkaline burn corneal wound: experimental study in rabbits.
Exp Eye Res
August 2025
Department of Surgery and Radiology, Faculty of Veterinary Medicine Science, Islamic Azad University, Karaj, Iran.
Corneal ulcers pose a significant threat to vision and require timely, effective intervention to prevent permanent damage. This experimental study evaluated the therapeutic potential of combining crushed limbal tissue with either bovine amniotic membrane (AM) or a conjunctival flap to enhance corneal wound healing in a rabbit model. Twenty-five New Zealand white rabbits were randomly assigned to five groups: (G1) untreated control, (G2) AM alone, (G3) conjunctival flap alone, (G4) AM with crushed limbal tissue, and (G5) conjunctival flap with crushed limbal tissue.
View Article and Find Full Text PDF