Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10119215 | PMC |
| http://dx.doi.org/10.1007/s00401-023-02563-3 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Optimizing Amphipathic Antimicrobial Peptides via Helical Wheel Rotation.
ChemMedChem
September 2025
Faculty of Pharmacy, PHENIKAA University, Hanoi, 12116, Vietnam.
Antimicrobial peptides (AMPs) have emerged as promising candidates for combating drug-resistant pathogens and certain cancer types. However, their therapeutic applications are often limited by undesired hemolytic activity, while many AMPs exhibit only moderate potency. Herein, the "helical wheel rotation" strategy as a simple, cost-effective, and modular approach to optimize the pharmacological properties of amphipathic α-helical AMPs without altering their amino acid composition is explored.
View Article and Find Full Text PDFHydrogen-Bond-Directed Chirality Transfer in Helical Polyacetylene-Perovskite-PDMS Elastomeric Films for Stretching-Tunable Multicolor Circularly Polarized Luminescence.
ACS Appl Mater Interfaces
September 2025
State Key Laboratory of Chemical Resource Engineering, Beijing 100029, China.
Circularly polarized luminescence (CPL) has emerged as a critical technology for anticounterfeiting and optical display applications due to its unique chiroptical properties. We report a multicolor CPL-emitting elastomeric film (P37/PSK@SiO-PDMS) that synergistically combines chiral helical polyacetylene (P37) and a surface-engineered perovskite (PSK@SiO) through hydrogen-bond-directed assembly. Confinement within the PDMS matrix drives P37 to self-assemble into a chiral supramolecular structure through hydrogen bonding, inducing a chiroptical inversion.
View Article and Find Full Text PDFThermotropic and Lyotropic Phase Behavior of Poly(γ-stearyl-l-glutamate)-Functionalized Nanoparticles.
Langmuir
September 2025
Centre québécois sur les matériaux fonctionnels/Quebec Centre for Advanced Materials (CQMF/QCAM), Chemistry Department, 801 Sherbrooke St. W., Montreal, Québec H3A 0B8, Canada.
Poly(γ-stearyl-l-glutamate) (PSLG) is a semiflexible synthetic polypeptide that forms both thermotropic and lyotropic liquid crystal (LC) phases. We previously showed that spherical nanoparticles (NPs) decorated with another semiflexible helical polymer, poly(hexyl isocyanate), form lyotropic nematic rather than cubic LC phases. In this work, PSLG ligands for functionalizing 4 nm ZrO NPs were prepared via N-carboxyanhydride ring-opening polymerization.
View Article and Find Full Text PDFCAA-related enlarged perivascular spaces are associated with abnormal angioarchitecture in human brain tissue: A key role for white matter atrophy?
J Cereb Blood Flow Metab
September 2025
iInstitut de Mécanique des Fluides de Toulouse (IMFT), Université de Toulouse, CNRS, INPT, Université Toulouse III - Paul Sabatier (UPS), Toulouse, France.
Cerebral Amyloid Angiopathy, a common age-related small vessel disease leading to hemorrhagic stroke, shares many characteristics with Alzheimer's disease: toxic amyloid deposits, microvascular alterations and enlarged perivascular spaces (EPVS). Together, PVS enlargement, reduced amyloid-β clearance and further accumulation form a vicious cycle underlying disease progression. Yet, the neuropathological correlates of EPVS, including the associated angioarchitecture, are poorly understood.
View Article and Find Full Text PDFtumor imaging of pre-clinical models via reflection-mode measurements of circular degree of polarization.
J Biomed Opt
December 2025
University of Toronto, Department of Medical Biophysics, Temerty Faculty of Medicine, Toronto, Ontario, Canada.
Significance: Tumor tissues exhibit contrast with healthy tissue in circular degree of polarization (DOP) images via higher magnitude circular DOP values and increased helicity-flipping. This phenomenon may enable polarimetric tumor detection and surgical/procedural guidance applications.
Aim: Depolarization metrics have been shown to exhibit differential responses to healthy and cancer tissue, whereby tumor tissues tend to induce less depolarization; however, the understanding of this depolarization-based contrast remains limited.