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http://dx.doi.org/10.1093/jmcb/mjad018 | DOI Listing |
AAPS PharmSciTech
September 2025
Nanotechnology Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.
J Mater Chem B
September 2025
Bioprocessing Technology Institute (BTI), Agency for Science, Technology and Research (A*STAR), 20 Biopolis Way, Centros #06-01, Singapore 138668, Republic of Singapore.
Non-viral gene delivery holds significant promise for the treatment of various diseases. Solid lipid nanoparticles (SLNs) are emerging as promising gene delivery vehicles due to their ease of manufacture and high stability. However, the development of efficient and safe SLNs remains a challenge.
View Article and Find Full Text PDFJ Control Release
August 2025
Department of Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, MD, USA; Institute for NanoBioTechnology, Johns Hopkins University, Baltimore, MD, USA; Translational Tissue Engineering Center, Johns Hopkins University School of Medicine, Baltimore, MD, USA.; Department
Adipose tissue plays a crucial role in energy metabolism and endocrine signaling. White adipose tissue (WAT), in particular, is a compelling target for therapeutic interventions in metabolic diseases due to its secretory capacity and abundance. Gene therapies hold promise for reprogramming adipocytes to enhance energy metabolism and facilitate the secretion of therapeutic proteins.
View Article and Find Full Text PDFMol Aspects Med
August 2025
Department of Sports Medicine, Tongji Hospital, School of Medicine, Tongji University, China. Electronic address:
Gene therapy offers a transformative approach for treating debilitating bone disorders by delivering therapeutic genetic material to target sites. The efficacy and safety of this approach are heavily reliant on the chosen delivery vehicle, either viral or non-viral vectors. Viral vectors are characterized by high transduction efficiency and the potential for long-term expression, as exemplified by Adeno-Associated Viruses (AAVs) and lentiviruses.
View Article and Find Full Text PDFPharmaceutics
August 2025
Institute of Polymers, Bulgarian Academy of Sciences, Akad. G. Bonchev St. 103-A, 1113 Sofia, Bulgaria.
Efficient nucleic acid delivery into target cells remains a critical challenge in gene therapy. Due to its advantages in biocompatibility and safety, recent research has increasingly focused on non-viral gene delivery. .
View Article and Find Full Text PDF