98%
921
2 minutes
20
Osteochondral allograft (OCA) transplantation has been used to treat a wide spectrum of cartilage deficiencies in the knee, including spontaneous necrosis of the knee. Studies reporting outcomes after OCA transplantation have shown reliable improvement in pain and return to activities of daily living. We describe a single-plug, press-fit technique for OCA transplantation with concomitant high tibial osteotomy to treat femoral condyle chondral defects in a varus knee. Pearls and pitfalls of this technique are presented; attention should be paid to correction of concomitant joint pathology and malalignment to facilitate osseointegration and survivorship of the allograft plug into host bone. Appropriate surgical timing and prompt allograft implantation help to maximize chondrocyte viability.
Download full-text PDF |
Source |
---|---|
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9984732 | PMC |
http://dx.doi.org/10.1016/j.eats.2022.10.012 | DOI Listing |
J Knee Surg
September 2025
Thompson Laboratory for Regenerative Medicine, University of Missouri Missouri Orthopaedic Institute, Columbia, United States.
This preclinical ex vivo study was conducted to evaluate the effects of submersion in saline or the Missouri Osteochondral Preservation System (MOPS®) solution during plug reaming on Day-0 viable chondrocyte density (%VCD) of osteochondral allograft (OCA) plugs used for osteochondral allograft transplantation (OCAT). Distal femoral OCAs preserved with MOPS were reamed to create cylindrical "plug" grafts using one of three techniques: submersion in MOPS (SG-MOPS), submersion in saline (SG-Saline), or reamer saturated with MOPS without OCA submersion (SR-MOPS). All plug reaming was performed using standardized instrumentation and technique to harvest 18-mm-diameter plugs.
View Article and Find Full Text PDFJ Orthop
November 2025
Musculoskeletal Research and Innovation Center, Department of Orthopaedic Surgery, MedStar Union Memorial Hospital, 201 E University Pkwy, Baltimore, MD, 21218, USA.
Background: Osteochondral defects of the knee are a frequent cause of pain that often require surgical intervention. Restorative procedures such as osteochondral autograft transplantation (OAT) and osteochondral allograft transplantation (OCA) aim to replace cartilage lesions with healthy autologous tissue or cadaveric tissue from the distal femur, respectively. Osteochondral graft donor sites are selected to optimize donor-recipient site congruity by assessing factors such as surface topography, cartilage thickness, and contact pressures.
View Article and Find Full Text PDFNat Commun
August 2025
Department of Gastroenterology, Xinqiao Hospital, Army Medical University, Chongqing, China.
Cholecystectomy represents the most prevalent biliary surgical procedure for gallbladder abnormalities. Growing evidence suggests that cholecystectomy is associated with an elevated risk of colorectal cancer. However, the underlying mechanism remains elusive.
View Article and Find Full Text PDFSci Transl Med
August 2025
Research Unit for Translational Nuclear Receptor Research, Division of Gastroenterology and Hepatology, Medical University of Graz, 8036 Graz, Austria.
Metabolic pressure shifts signaling pathways of nuclear receptors, including the bile acid receptor FXR, which are sensitive to nutritional inputs. We performed an FXR ChIP-seq-centered multiomic analysis of liver biopsy samples from individuals with or without obesity, who were treated with either placebo or the FXR agonist obeticholic acid, to define metabolic adaptions of FXR signaling pathways. FXR occupied substantially more DNA binding sites in individuals with obesity, and FXR activation by OCA robustly changed the transcriptional output.
View Article and Find Full Text PDFKnee
August 2025
NYU Langone Orthopedics, Division of Sports Medicine 333 E 38th St, 4th Floor, New York, NY 10016, United States.
Purpose: To identify demographic or radiographic predictors of sagittal tibial tuberosity-trochlear groove (sTT-TG) distance utilizing a cohort of patellofemoral surgical patients.
Methods: Patients who underwent an osteochondral allograft (OCA) transplantation or autologous chondrocyte implantation (ACI) from 2010 to 2020 were included if they had patellofemoral high-grade lesions and preoperative magnetic resonance imaging (MRI). Patient demographics, radiographic measurements such as coronal TT-TG, Caton-Deschamps index (CDI), and trochlear dysplasia were recorded.