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Background: While reductions in child mortality have been observed across sub-Saharan African countries in the last 30 years, narrowing the gaps in under-five mortality across socioeconomic groups also requires an understanding of the multiple associations between health and welfare and socioeconomic drivers. We examined the probability density distributions in under-five mortality within countries and joint pathways of under-five mortality and wealth over time.
Methods: We used 69 Demographic and Health Surveys and 19 Malaria Indicator Surveys from 30 sub-Saharan African countries, with each country having at least two surveys conducted since 2000. We constructed a cross-country wealth index and estimated under-five death prevalence. We examined the pure distribution in under-five mortality prevalence and the joint probability distribution of wealth and under-five mortality prevalence over time, including the area of confidence ellipse which spanned the two dimensions of mortality and wealth and covered 75% of the mass of the joint distribution.
Results: Most countries experienced decreases in under-five mortality along with increases in wealth over time. However, we observed great variations in the evolution of the joint distributions across countries over time. For instance, the areas of confidence ellipse ranged from 0.178 in Ethiopia (2000) to 1.119 in Angola (2006). The change (over time) in the area of confidence ellipses ranged from 0.010 in Tanzania to 0.844 in Angola between the 2000s and 2010s. The ranking of country performance on under-five mortality varied greatly, depending on whether performance summary indicators were based on disaggregation by wealth or on full non-disaggregated distributions.
Conclusions: Our analysis points to the relevance of full distributions of health and joint distributions of health and wealth as complementary indicators of distributions of health across socioeconomic status, in assessing country performance on health.
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http://dx.doi.org/10.7189/jogh.13.04009 | DOI Listing |
Infect Genet Evol
September 2025
Next Generation Sequencing Unit, School of Biomedical Sciences, Faculty of Health Sciences, University of the Free State, Bloemfontein, South Africa; Division of Virology, School of Pathology, Faculty of Health Sciences, University of the Free State, Bloemfontein, South Africa. Electronic address: N
The sub-Saharan African region bears the highest burden of rotavirus-associated morbidity and mortality, with substantial genetic diversity observed in circulating strains despite vaccine introduction. The G8 genotype, originally predominant in bovine strains, has increasingly become prevalent in humans, suggesting a possible interface of animal-to-human transmission and highlighting its role in African strain diversity. In this study, we performed whole genome sequencing and evolutionary analysis of 21 archival G8P[4] strains collected through gastroenteritis surveillance in South Africa between 2009 and 2021 from children under five years of age.
View Article and Find Full Text PDFPaediatr Perinat Epidemiol
September 2025
Rollins School of Public Health, Emory University, Atlanta, Georgia, USA.
Background: Studies of child mortality that employ minimally invasive tissue sampling (MITS) produce highly accurate cause of death data; however, selection bias may render these as non-representative of their underlying populations.
Objectives: Estimate cause-specific mortality fractions and rates for the five most frequent causes-underlying and others in the chain of events leading to death-among stillbirths, neonatal, infant and child deaths-in Sub-Saharan Africa and South Asia, adjusted for any identified selection biases.
Methods: The Child Health and Mortality Prevention Surveillance (CHAMPS) Network collects standardised, population-based, longitudinal data on causes of death among stillbirths and under-five children in 12 catchments in seven countries in Sub-Saharan Africa and South Asia.
Paediatr Perinat Epidemiol
September 2025
Department of Critical Care Medicine, Taizhou Hospital of Zhejiang Province Affiliated to Wenzhou Medical University, Taizhou, China.
Background: Lower respiratory infections (LRI) are a leading cause of death among children aged 0 to 14 globally. LRI burden estimates remain incomplete, especially in resource-limited settings.
Objective: To assess the global, regional, and national burden of LRI in children, analyse trends in incidence, mortality, and disability-adjusted life-years (DALYs), and predict future burden projections from 2022 to 2035, exploring variations in major bacterial pathogens.
Front Microbiol
August 2025
Center for Microbiology Research, Kenya Medical Research Institute, Nairobi, Kenya.
Introduction: Enterotoxigenic (ETEC) is a significant cause of diarrheal morbidity and mortality among children under 5 years, particularly in low and middle-income countries. This study aimed to determine the prevalence of ETEC and associated risk factors among children under five presenting with diarrhea in health facilities in Mukuru slums of Nairobi, Kenya, where poor sanitation and hygiene practices are prevalent.
Methods: Using a cross-sectional design, we recruited 387 children under five years of age with acute diarrhea.
Trop Med Int Health
September 2025
Department of International Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA.
Objectives: Childhood mortality is a key indicator of progress in health and development in low- and middle-income countries, traditionally measured through household surveys with face-to-face interviews. This study explored an alternative approach that used mobile phone interviews with women in Mozambique.
Methods: Using two sampling approaches, we interviewed women of reproductive age about their pregnancy history through mobile phones.