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Article Abstract
The recently released EACTS/EACTA/EBCP guidelines on cardiopulmonary bypass (CPB) in adult cardiac surgery [...].
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9918189 | PMC |
| http://dx.doi.org/10.3390/jcm12030806 | DOI Listing |
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Towards goal-directed perfusion - Part I: Developing physiology-inspired mathematical framework using high-resolution paediatric CPB data.
Perfusion
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Cardiac Surgery Department, Bristol Royal Children's Hospital, Bristol, UK.
BackgroundDuring cardiopulmonary bypass (CPB), goal-directed perfusion (GDP) seeks to match oxygen delivery to metabolic demand, but the dynamics of oxygen extraction and intraoperative oxygen demand remain poorly understood, especially in paediatric populations. Existing models rely on limited data and assume, for example, a linear relationship between log oxygen demand and temperature.MethodsWe developed GARIX (Global AutoRegressive Integrated model with eXogenous variables and an equilibrium force) to predict minute-by-minute changes in oxygen extraction ratio (OER) using high-resolution intraoperative data.
View Article and Find Full Text PDFExtracorporeal blood purification (EBP) is an emerging technique for reducing elevated levels of inflammatory mediators and/or endotoxins in critically ill patients with sepsis or other hyperinflammatory conditions. The oXiris filter combines endotoxin adsorption, cytokine adsorption, hemofiltration and anti-thrombosis, and an emerging body of evidence demonstrates its use in critical care patients with hyperinflammatory conditions and acute kidney injury (AKI). A group of Asia-Pacific experts convened to formulate consensus statements for the use of the oXiris filter based on a comprehensive review of publications.
View Article and Find Full Text PDFIn-Hospital Mortality in Children Undergoing Congenital Heart Surgery in North Brazil: A 9-Year Analysis From a Regional Referrel Center.
World J Pediatr Congenit Heart Surg
September 2025
Postgraduate Program in Health Sciences, Medical School, Federal University of Amazonas (UFAM), Manaus, Amazonas, Brazil.
To analyze in-hospital mortality in children undergoing congenital heart interventions in the only public referral center in Amazonas, North Brazil, between 2014 and 2022. This retrospective cohort study included 1041 patients undergoing cardiac interventions for congenital heart disease, of whom 135 died during hospitalization. Records were reviewed to obtain demographic, clinical, and surgical data.
View Article and Find Full Text PDFNovel mode of heart and lung machine for real-time identification of cerebral autoregulation impairments during cardiac surgery with cardiopulmonary bypass: prospective observational study.
Minerva Anestesiol
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Background: Postoperative cognitive dysfunction (POCD) occurs in 20% to 80% of patients following cardiac surgical interventions. The incidence of delirium is from 20% to 50%. Impaired cerebral autoregulation (CA) during cardiopulmonary bypass (CPB) contributes to these issues.
View Article and Find Full Text PDFCoagulation Disorders in Patients With Acute Respiratory Distress Syndrome Following Acute Aortic Dissection: A Prospective Observational Study.
Rev Cardiovasc Med
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Center for Cardiac Intensive Care, Beijing Anzhen Hospital, Capital Medical University, 100029 Beijing, China.
Background: Coagulation disorders are potentially one of the most important pathogeneses of acute respiratory distress syndrome (ARDS) following acute type A aortic dissection (ATAAD). This study aimed to determine whether aortic dissection singularly and cardiopulmonary bypass (CPB) surgery can activate coagulation pathways, promoting ARDS development in patients with ATAAD.
Methods: A total of 450 patients who received treatment at Beijing Anzhen Hospital, Capital Medical University, between March 2023 and February 2024 were consecutively enrolled in this prospective cohort study.