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Objective: To conduct a retrospective analysis comparing traditional human-based consenting to an automated chat-based consenting process.
Materials And Methods: We developed a new chat-based consent using our IRB-approved consent forms. We leveraged a previously developed platform (Gia, or "Genetic Information Assistant") to deliver the chat content to candidate participants. The content included information about the study, educational information, and a quiz to assess understanding. We analyzed 144 families referred to our study during a 6-month time period. A total of 37 families completed consent using the traditional process, while 35 families completed consent using Gia.
Results: Engagement rates were similar between both consenting methods. The median length of the consent conversation was shorter for Gia users compared to traditional (44 vs. 76 minutes). Additionally, the total time from referral to consent completion was faster with Gia (5 vs. 16 days). Within Gia, understanding was assessed with a 10-question quiz that most participants (96%) passed. Feedback about the chat consent indicated that 86% of participants had a positive experience.
Discussion: Using Gia resulted in time savings for both the participant and study staff. The chatbot enables studies to reach more potential candidates. We identified five key features related to human-centered design for developing a consent chat.
Conclusion: This analysis suggests that it is feasible to use an automated chatbot to scale obtaining informed consent for a genomics research study. We further identify a number of advantages when using a chatbot.
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http://dx.doi.org/10.1101/2023.01.23.525221 | DOI Listing |
J Ethn Subst Abuse
September 2025
An-Najah National University, Nablus, Palestine.
Preoperative drug screening is not routinely performed in Palestine, which poses challenges for medical management, especially during anesthesia for surgical procedures. We aimed to determine the prevalence and types of illicit drugs through preoperative screening of patients undergoing elective surgeries and to compare these findings with self-reported drug use. A cross-sectional study was conducted in 2024 in the surgical departments of two tertiary hospitals.
View Article and Find Full Text PDFAdv Physiol Educ
September 2025
Division of Epidemiology and Biostatistics, St. John's Medical College, Bangalore, Karnataka, India.
The amphibian dissection for medical students was halted by the restrictions imposed by the National regulatory guidelines, prompting medical curricula to revise and innovate instructional methods. Hence there is a critical need for potential innovative solutions to enhance students' understanding of physiological concepts. Therefore, this study aimed (a) to evaluate the gain in knowledge and retention with computer assisted simulation (CAS) vs traditional (TT) teaching learning strategies in first year medical and paramedical students, and (b) to obtain students' and faculty feedback about strengths and limitations of both strategies.
View Article and Find Full Text PDFTher Drug Monit
September 2025
Departments of Pharmacology, and.
Background: Fluconazole-tacrolimus interactions occur, but the additional effect of ritonavir is emphasized here, underscoring the need for careful prescription reconciliation in renal transplant recipients living with HIV-AIDS to prevent accidental ritonavir coadministration and inadvertent tacrolimus toxicity. The findings provide valuable insight for therapeutic drug monitoring (TDM) specialists. Patient informed consent was obtained for publication of the anonymized data.
View Article and Find Full Text PDFAnn Acad Med Singap
August 2025
Dementia Research Centre (Singapore), Lee Kong Chian School of Medicine, Nanyang Technology University, Singapore.
Introduction: Interpretation and analysis of magnetic resonance imaging (MRI) scans in clinical settings comprise time-consuming visual ratings and complex neuroimage processing that require trained professionals. To combat these challenges, artificial intelligence (AI) techniques can aid clinicians in interpreting brain MRI for accurate diagnosis of neurodegenerative diseases but they require extensive validation. Thus, the aim of this study was to validate the use of AI-based AQUA (Neurophet Inc.
View Article and Find Full Text PDFAnn Nucl Med
September 2025
Department of Nuclear Medicine, Marmara University School of Medicine, Istanbul, Turkey.
Objective: This study aims to systematically evaluate the inter- and intra-observer agreement regarding lesions with uncertain malignancy potential in Ga-68 PSMA PET/CT imaging of prostate cancer patients, utilizing the PSMA-RADS 2.0 classification system, and to emphasize the malignancy evidence associated with these lesions.
Methods: We retrospectively reviewed Ga-68 PSMA PET/CT images of patients diagnosed with prostate cancer via histopathology between December 2016 and November 2023.