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In this research work, a new deep learning model named VGG-COVIDNet has been proposed which can classify COVID-19 cases from normal cases over X-Rays and CT scan images of lungs. Medical practitioners use the X-Rays and CT scan images of lungs to identify whether a person is infected from COVID or not. In present times, it is very important to give real time COVID prediction with high reliability of results. Deep learning models equipped with machine learning support have been found very influential in accurate prediction of COVID or Non-COVID cases in real time. However, there are some limitations associated with the performance of these model which are model size, achieving good balance of model size and accuracy, and making a single model fitting well for both X-Ray and CT Scan image datasets. Keeping in mind these performance constraints, this new model (VGG-COVIDNet) has been proposed for real time prediction of COVID cases with good balance of model size and accuracy working well for both type of datasets (CT Scan and X-Ray). In order to control model size, an improved version of VGG-16 architecture has been proposed which contains only 13 convolutional layers and 5 fully connected layers. Multiple dropout layers have been added in the proposed architecture which can drop some percentage of features and applies random transformations to decrease the model over-fitting issue. Keeping in mind the primary goal to increase the model accuracy the proposed model has been trained on different datasets with ReLU activation function which is one of the best non-linear activation functions. Four different capacity datasets with CT scan and X-Ray images have been used to validate the performance of proposed model. The proposed model gives an overall accuracy of more than 90% on both types of input datasets i.e. X-Ray and CT Scan.
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http://dx.doi.org/10.1016/j.procs.2023.01.169 | DOI Listing |
J Cannabis Res
September 2025
Department of EconomicsMA in Applied Economics, Lebanese American University, P.O. Box: 13-5053, Beirut, Lebanon.
Amidst the global shift toward cannabis legalization, this study examines medical cannabis (MC) sales as an indicator of economic activity and innovation. It explores associations between MC sales, and variables including tobacco use, alcohol consumption, amphetamine, cocaine and cannabis prevalence, and gross domestic product (GDP), using a fixed effects (FE) panel regression model. It also evaluates associations between cannabis legalization and MC sales over time using a dynamic Difference-in-Differences (DiD) approach with multiple time periods.
View Article and Find Full Text PDFEMBO Mol Med
September 2025
Institute for Regenerative Medicine, Medical Innovation Center and State Key Laboratory of Cardiovascular Diseases, Shanghai East Hospital, National Stem Cell Translational Resource Center & Ministry of Education Stem Cell Resource Center, Frontier Science Center for Stem Cell Research, School of Li
Primary microcephaly, a rare congenital condition characterized by reduced brain size, occurs due to impaired neurogenesis during brain development. Through whole-exome sequencing, we identified compound heterozygous loss-of-function mutations in CENTRIN 3 (CETN3) in a 5-year-old patient with primary microcephaly. As CETN3 has not been previously linked to microcephaly, we investigated its potential function in neurodevelopment in human pluripotent stem cell-derived cerebral organoids.
View Article and Find Full Text PDFCardiovasc Intervent Radiol
September 2025
Department of Radiology, Seoul National University College of Medicine, Seoul National University Bundang Hospital, 82, Gumi-ro 173Beon-gil, Bundang-gu, Seongnam-si, Gyeonggi-do, Republic of Korea.
Purpose: To evaluate the preclinical efficacy and safety of transarterial chemoembolization (TACE) using doxorubicin-loaded biocompatible cellulose nanoparticles in a rabbit VX2 liver tumor model.
Materials And Methods: Following institutional animal care committee approval, 23 rabbits with VX2 liver tumors were randomized into three groups: Group A (n = 9) received doxorubicin-loaded cellulose nanoparticles with ethiodized oil; Group B (n = 9) received doxorubicin with ethiodized oil; and Group C (n = 5) served as untreated controls. Tumor size was monitored via ultrasound for 4 weeks, and serum liver enzymes (aspartate transaminase and alanine transaminase) were measured on days 1, 3, and 7 to assess hepatotoxicity.
EMBO Rep
September 2025
Institute for Stem Cell Science and Regenerative Medicine (inStem), GKVK post, Bellary Road, Bangalore, Karnataka, 560065, India.
Immune cells are increasingly recognized as nutrient sensors; however, their developmental role in regulating growth under homeostasis or dietary stress remains elusive. Here, we show that Drosophila larval macrophages, in response to excessive dietary sugar (HSD), reprogram their metabolic state by activating glycolysis, thereby enhancing TCA-cycle flux, and increasing lipogenesis-while concurrently maintaining a lipolytic state. Although this immune-metabolic configuration correlates with growth retardation under HSD, our genetic analyses reveal that enhanced lipogenesis supports growth, whereas glycolysis and lipolysis are growth-inhibitory.
View Article and Find Full Text PDFActa Ortop Mex
September 2025
Servicio de Ortopedia y Traumatología, Hospital de San Rafael, Hospitales Pascual. Cádiz, España.
Introduction: anatomical deformities such as developmental dysplasia of the hip (DDH) and Perthes disease represent a challenge for reconstruction. The use of 3D-printed models can be helpful for assessing the deformity, bone mass, implant size, and orientation.
Objectives: to prospectively evaluate the outcomes of 3D simulation in primary total hip arthroplasty.