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http://dx.doi.org/10.4103/ijstd.ijstd_103_21 | DOI Listing |
Medicine (Baltimore)
September 2025
Department of Orthopaedics, Beijing Ditan Hospital Affiliated to Capital Medical University, Beijing, China.
Osteoporosis is a common metabolic bone disease characterized by decreased bone density and increased fracture risk. Human immunodeficiency virus (HIV) infection is considered one of the independent risk factors for osteoporosis, but its specific mechanisms are not yet clear. This study aims to explore the relationship between HIV infection and osteoporosis based on the National Health and Nutrition Examination Survey database and to analyze the impact of related clinical factors on bone density.
View Article and Find Full Text PDFHIV AIDS (Auckl)
September 2025
Department of Respiratory Medicine, Beijing Ditan Hospital, Capital Medical University, Beijing, People's Republic of China.
Introduction: The advent of highly active antiretroviral therapy (HAART) has changed infection by human immunodeficiency virus (HIV) from an acute disease to a manageable chronic condition; however, pulmonary complications continue to affect patient quality of life. The goal of this research was to examine the link between CD4+ levels, viral load, and respiratory function in patients infected with HIV.
Methods: Patients were grouped as HIV-infected and non-infected (1:2 ratio).
Front Cell Infect Microbiol
September 2025
Fundació Lluita contra les Infeccions, Badalona, Spain.
Background: The intestinal microbiota composition has been linked to neurocognitive impairment in people with HIV (PWH). However, the potential interplay of microbial species and related metabolites, particularly in the context of an HIV cure strategy remains underexplored. The BCN02 trial evaluated the impact of romidepsin (RMD), used as a HIV-1 latency reversing agent and with reported beneficial neurological effects, combined with the MVA.
View Article and Find Full Text PDFClin Microbiol Infect
September 2025
Organización Nacional de Trasplante (ONT), Madrid, Spain.
Objectives: There is limited information on the use of organs from HIV-positive donors (HIV D+) for HIV-positive recipients (HIV R+) in Europe. In some countries the use of HIV D+ organs is prohibited by law. This study aimed to assess the attitudes of Spanish kidney and liver transplant (KT/LT) teams towards HIV D+/R+ KT/LT through a nationwide survey, and to evaluate the current situation across Europe regarding legislation and reported cases.
View Article and Find Full Text PDFNPJ Drug Discov
September 2025
Department of Molecular Biophysics and Biochemistry, Yale University School of Medicine, New Haven, CT USA.
A strategy to functionally cure AIDS by eliminating latent HIV-1 reservoirs involves non-nucleoside reverse transcriptase inhibitors (NNRTIs) that promote pyroptosis of HIV-1 infected cells. These NNRTIs stimulate dimerization of the Gag-Pol polyprotein, resulting in premature HIV-1 protease (PR) dimerization and cleavage of intracellular CARD8. A unique cell-based high-throughput screen was developed to identify potent compounds activating the CARD8 inflammasome through Gag-Pol dimerization.
View Article and Find Full Text PDF