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We describe the design and performance of a multimodal and multifunctional adaptive optics (AO) system that combines scanning laser ophthalmoscopy (SLO) and optical coherence tomography (OCT) for simultaneous retinal imaging at 13.4 Hz. The high-speed AO-OCT channel uses a 3.4 MHz Fourier-domain mode-locked (FDML) swept source. The system achieves exquisite resolution and sensitivity for pan-macular and transretinal visualization of retinal cells and structures while providing a functional assessment of the cone photoreceptors. The ultra-high speed also enables wide-field scans for clinical usability and angiography for vascular visualization. The FDA FDML-AO system is a powerful platform for studying various retinal and neurological diseases for vision science research, retina physiology investigation, and biomarker development.
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9872887 | PMC |
http://dx.doi.org/10.1364/BOE.462594 | DOI Listing |
Light Sci Appl
September 2025
State Key Laboratory of Flexible Electronics, Institute of Advanced Materials (IAM), Nanjing University of Posts & Telecommunications (NUPT), Nanjing, 210023, China.
As the demand for edge platforms in artificial intelligence increases, including mobile devices and security applications, the surge in data influx into edge devices often triggers interference and suboptimal decision-making. There is a pressing need for solutions emphasizing low power consumption and cost-effectiveness. In-sensor computing systems employing memristors face challenges in optimizing energy efficiency and streamlining manufacturing due to the necessity for multiple physical processing components.
View Article and Find Full Text PDFLight Sci Appl
September 2025
Laboratory of Quantum Information, University of Science and Technology of China, 230026, Hefei, China.
Quantum imaging with spatially entangled photons offers advantages such as enhanced spatial resolution, robustness against noise, and counterintuitive phenomena, while a biphoton spatial aberration generally degrades its performance. Biphoton aberration correction has been achieved by using classical beams to detect the aberration source or scanning the correction phase on biphotons if the source is unreachable. Here, a new method named position-correlated biphoton Shack-Hartmann wavefront sensing is introduced, where the phase pattern added on photon pairs with a strong position correlation is reconstructed from their position centroid distribution at the back focal plane of a microlens array.
View Article and Find Full Text PDFMicrosyst Nanoeng
September 2025
Department of Ophthalmology, Key Laboratory of Precision Medicine for Eye Diseases of Zhejiang Province, Center for Rehabilitation Medicine,, Zhejiang Provincial People's Hospital (Affiliated People's Hospital, Hangzhou Medical College), Hangzhou, 314408, China.
Retinal surgery is one of the most delicate and complex operations, which is close to or even beyond the physiological limitation of the human hand. Robots have demonstrated the ability to filter hand tremors and motion scaling which has a promising output in microsurgery. Here, we present a novel soft micron accuracy robot (SMAR) for retinal surgery and achieve a more precise and safer operation.
View Article and Find Full Text PDFACS Nano
September 2025
Frontiers Science Center for Transformative Molecules, State Key Laboratory of Synergistic Chem-Bio Synthesis, School of Chemistry and Chemical Engineering, Shanghai Jiao Tong University, Shanghai 200240, P. R. China.
Dynamic micro/nano-structured surfaces play pivotal roles in biological systems and engineering applications. Despite considerable progress has been made in fabricating precisely ordered architectures, achieving controlled motion in top-down fabricated structures remain a formidable challenge. Here, we introduce an advanced dynamic micron-nano optical platform featuring hierarchical microscale wrinkles integrated with ordered nanoscale arrays.
View Article and Find Full Text PDFZhonghua Yan Ke Za Zhi
September 2025
Department of Respiratory, The First People's Hospital of Xianyang, Xianyang 712000, China.
A 65-year-old male patient presented with "blurred vision in the right eye for 1 week". At the first visit, the best corrected visual acuity (BCVA) of both eyes was 0.8, no obvious abnormalities were observed in fundus examination, and optical coherence tomography (OCT) revealed the loss of outer retinal layers adjacent to the macula in the right eye.
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