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Serum N-Glycan Signatures as Potential Biomarkers for the Detection and Monitoring of IgG4-Related Disease.
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Department of Rheumatology and Immunology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China.
IgG4-related disease (IgG4-RD) is a rare disease characterized by lymphoplasmatic infiltration and fibrosis in multiple organs, often accompanied by elevated serum levels of IgG4. Considerable efforts have been devoted to the diagnosis of IgG4-related diseases, but its etiology and pathogenesis remain poorly understood. The total serum N-glycome profile can reflect disease phenotypes with specific serum N-glycans serving as potential biomarkers for diagnosis and prognosis.
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University of Antwerp, Faculty of Medicine and Health Sciences, Department of Immunology, Allergology, Rheumatology and the Infla-Med Centre of Excellence.
Purpose Of Review: Mast cell degranulation in anaphylaxis can result from both IgE-dependent and IgE-independent mechanisms. The two conditions differ in terms of phenotype, diagnosis and specific therapeutic targets.
Recent Findings: Genetic factors and IgE-sialylation might enhance IgE-dependent degranulation.
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Antibodies play a vital role in the immune system, with distinct isotypes having unique tropisms and performing specialized functions. Of these isotypes, IgE is the least abundant in circulation yet plays a critical role in defense against parasitic infection and allergic reactions. IgE is also heavily N-linked glycosylated, a posttranslational modification that influences receptor interactions of effector responses.
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Immunoglobulins (Ig) are proteins that help fight infections. IgG (IgG1, IgG2, IgG3, IgG4), IgM, IgA, IgD, and IgE are the five immunoglobulin subtypes that make up the majority of our immune system. Beneficial effects have been observed on the administration of Ig in diseases like Kawasaki, multiple myositis, chronic inflammatory demyelinating polyneuropathy (CIDP), and immune thrombocytopenia purpura (ITP).
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