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The accuracy of exposure judgments, particularly for scenarios where only qualitative information is available or a systematic approach is not used, has been evaluated and shown to have a relatively low level of accuracy. This is particularly true for dermal exposures, where less information is generally available compared to inhalation exposures. Relatively few quantitative validation efforts have been performed for scenarios where dermal exposures are of interest. In this study, a series of dermal exposure judgments were collected from 90 volunteer U.S. occupational health practitioners in a workshop format to assess the accuracy of their judgments for three specific scenarios. Accuracy was defined as the ability of the participants to identify the correct reference exposure category, as defined by the quantitative exposure banding categories utilized by the American Industrial Hygiene Association (AIHA). The participants received progressively additional information and training regarding dermal exposure assessments and scenario-specific information during the workshop, and the relative accuracy of their category judgments over time was compared. The results of the study indicated that despite substantial education and training in exposure assessment generally, the practitioners had very little experience in performing dermal exposure assessments and a low level of comfort in performing these assessments. Further, contrary to studies of practitioners performing inhalation exposure assessments demonstrating a trend toward underestimating exposures, participants in this study consistently overestimated the potential for dermal exposure without quantitative data specific to the scenario of interest. Finally, it was found that participants were able to identify the reference or "true" category of dermal exposure acceptability when provided with relevant, scenario-specific dermal and/or surface-loading data for use in the assessment process. These results support the need for additional training and education of practitioners in performing dermal exposure assessments. A closer analysis of default loading values used in dermal exposure assessments to evaluate their accuracy relative to real-world or measured dermal loading values, along with consistent improvements in current dermal models, is also needed.
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http://dx.doi.org/10.1080/15459624.2023.2173365 | DOI Listing |
Biomater Adv
September 2025
Department of Applied Science and Technology (DISAT), Politecnico di Torino, Corso Duca Degli Abruzzi 24, 10129 Torino, Italy.
Tailoring surface characteristics is key to guiding scaffold interaction with the biological environment, promoting successful biointegration while minimizing immune responses and inflammation. In cardiac tissue engineering, polyvinylidene fluoride (PVDF) is a material of choice for its intrinsic piezoelectric properties, which can be enhanced through electrospinning, also enabling the fabrication of nanofibrous structures mimicking native tissue. However, the inherent hydrophobicity of PVDF can hinder its integration with biological tissues.
View Article and Find Full Text PDFEnviron Pollut
September 2025
State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing, 100085, China; Zhejiang Key Laboratory of Environment and Health of New Pollutants, School of Environment, Hangzhou Institute for Advanced Study, U
Per- and polyfluoroalkyl substances (PFAS) are extensively used in the petrochemical industry and pose considerable risks to the environment. However, systematic research on PFAS contamination in petrochemical industrial parks remains limited. This study focused on the occurrence, spatial distribution, and sources of 20 typical PFAS in soil (n = 19) and groundwater (n = 13) samples from a petrochemical industrial park in China.
View Article and Find Full Text PDFFood Chem Toxicol
September 2025
Science Strategies, LLC, PMB 1111, 2795 E. Cottonwood Parkway, Suite 300, Salt Lake City, UT 84121.
Tetrabromobisphenol A (TBBPA) is the most extensively used brominated flame retardant worldwide, primarily employed reactively in printed circuit boards and additively in plastic housings of electronic equipment. This study systematically evaluates human exposure to TBBPA from electronic devices and characterizes associated risks. A targeted literature review of 55 peer-reviewed studies published over the past 25 years was conducted, focusing on global TBBPA occurrence in environmental media, occupational and residential settings, and biological matrices.
View Article and Find Full Text PDFCrit Rev Toxicol
September 2025
Procter and Gamble, Mason, OH, USA.
A comprehensive review of existing toxicity and human exposure data for the ultraviolet filter avobenzone (butyl methoxydibenzoylmethane) was conducted to assess its safety as currently used in over-the-counter sunscreen formulations. Avobenzone has a suitable safety profile without any clear markers of toxicity or endpoints of concern. There are sufficient clinical studies and and toxicity studies in animal models to assess avobenzone's pharmacokinetics, pharmacodynamics, and potential toxicological properties, supportive of its long history of safe use.
View Article and Find Full Text PDFAnn Work Expo Health
September 2025
Division of Environmental Health Sciences, School of Public Health, University of Minnesota Twin Cities, Minneapolis, MN 55455, United States.
Antineoplastic drugs can persist on surfaces in human and veterinary oncology clinics where they are administered, resulting in potentially hazardous exposures for healthcare workers and cancer patient caregivers. To assess potential surface contamination in occupational settings, a new liquid chromatography-selected reaction monitoring-mass spectrometry (LC-SRM-MS/MS) method was developed to simultaneously detect six commonly used antineoplastic drugs. A surface wipe and desorption method was optimized for cyclophosphamide, doxorubicin, methotrexate, etoposide, paclitaxel, and 5-fluorouracil with drug desorption recoveries ranging from 49% to 79%.
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