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Room-temperature liquid metal (LM)-based electronics is expected to bring advancements in future soft electronics owing to its conductivity, conformability, stretchability, and biocompatibility. However, various difficulties arise when patterning LM because of its rheological features such as fluidity and surface tension. Numerous attempts are made to overcome these difficulties, resulting in various LM-patterning methods. An appropriate choice of patterning method based on comprehensive understanding is necessary to fully utilize the unique properties. Therefore, the authors aim to provide thorough knowledge about patterning methods and unique properties for LM-based future soft electronics. First, essential considerations for LM-patterning are investigated. Then, LM-patterning methods-serial-patterning, parallel-patterning, intermetallic bond-assisted patterning, and molding/microfluidic injection-are categorized and investigated. Finally, perspectives on LM-based soft electronics with unique properties are provided. They include outstanding features of LM such as conformability, biocompatibility, permeability, restorability, and recyclability. Also, they include perspectives on future LM-based soft electronics in various areas such as radio frequency electronics, soft robots, and heterogeneous catalyst. LM-based soft devices are expected to permeate the daily lives if patterning methods and the aforementioned features are analyzed and utilized.
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http://dx.doi.org/10.1002/advs.202205795 | DOI Listing |
Cancer Lett
September 2025
Department of Hematology, The Affiliated Huaian No.1 People's Hospital of Nanjing Medical University, Northern Jiangsu Institute of Clinical Medicine, Nanjing Medical University, Huaian, 223300, Jiangsu Province, China; Key Laboratory of Autoimmune Diseases of Huaian City, Huaian, 223300, Jiangsu Pr
CAR-T cell therapy, as a representative technology in cancer immunotherapy, has demonstrated notable success in the treatment of hematologic malignancies; however, a significant proportion of patients fail to achieve sustained remission. Through the analysis of bone marrow sequencing data prior to CD19 CAR-T cell therapy, we identified cellular adhesion as a pivotal factor influencing clinical outcomes. We developed a model to predict B-ALL treatment efficacy based on the core genes associated with cellular adhesion, which was validated in our clinical cohort.
View Article and Find Full Text PDFFood Chem
September 2025
Group of Chemical Analysis and Chemometrics, Department of Chemistry, Federal University of Paraná, P.O. Box: 19032, Curitiba, PR 81531-980, Brazil. Electronic address:
Yerba mate, a key crop in South America, is prized for its pleasant taste and high organoleptic quality, often linked to lower branch content. To quantify branch content and authenticate high-quality samples (less than 30 % m/m branch content), a Chemometrics-assisted Color Histogram-based Analytical System (CACHAS) was employed. Using Hue-Saturation-Value (HSV) histograms, Partial Least Squares (PLS) demonstrated excellent predictive performance, achieving a root mean square error (RMSEP) of 4.
View Article and Find Full Text PDFBiomater Adv
September 2025
Graduate School of Medical and Dental Science, Institute of Science Tokyo, 15-45 Yushima, Bunkyo, Tokyo, 113-8510, Japan; Advanced Central Research Organization, Teikyo University, 2-11-1, Kaga, Itabashi, Tokyo, 173-8605, Japan.
This review concentrates on the electroactive ceramic biointerfaces inspired by bone piezoelectricity for advanced ceramic biomaterials. Bone generates electrical potentials through the piezoelectric properties of collagen fibrils and apatite minerals under mechanical loading. These electrical signals influence osteoconductivity and regenerative capacity by osteogenic cells.
View Article and Find Full Text PDFProc Natl Acad Sci U S A
September 2025
McKetta Department of Chemical Engineering, The University of Texas at Austin, Austin, TX 78712.
Many soft, tough materials have emerged in recent years, paving the way for advances in wearable electronics, soft robotics, and flexible displays. However, understanding the interfacial fracture behavior of these materials remains a significant challenge, owing to the difficulty of quantifying the respective contributions from viscoelasticity and damage to energy dissipation ahead of cracks. This work aims to address this challenge by labeling a series of polymer networks with fluorogenic mechanophores, subjecting them to T-peel tests at various rates and temperatures, and quantifying their force-induced damage using a confocal microscope.
View Article and Find Full Text PDFAdv Mater
September 2025
Department of Mechanical Engineering, Pohang University of Science and Technology, Pohang, 37673, South Korea.
Wearable bioelectronics have advanced dramatically over the past decade, yet remain constrained by their superficial placement on the skin, which renders them vulnerable to environmental fluctuations and mechanical instability. Existing microneedle (MN) electrodes offer minimally invasive access to dermal tissue, but their rigid, bulky design-often 100 times larger and 10,000 times stiffer than dermal fibroblasts-induces pain, tissue damage, and chronic inflammation, limiting their long-term applicability. Here, a cell-stress-free percutaneous bioelectrode is presented, comprising an ultrathin (<2 µm), soft MN (sMN) that dynamically softens via an effervescent structural transformation after insertion.
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