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Introduction: Despite universal newborn screening, there is no comprehensive surveillance system to understand the sickle cell disease population in Wisconsin.
Methods: We initiated the development of a sickle cell disease surveillance system by linking newborn screening data and electronic health records from 2 large tertiary health care institutions in Wisconsin: Children's Wisconsin and Froedtert Hospital.
Results: There were 1478 individuals within the 3 data sources. One hundred thirty-two (82%) of 159 identified by newborn screening from 2013 through 2019 received care at Children's Wisconsin. The majority of individuals with sickle cell disease at Children's Wisconsin and Froedtert Hospital resided in Milwaukee County.
Discussion: The new surveillance program will increase our understanding of the sickle cell disease population in Wisconsin and help improve quality of care and health outcomes.
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Aust Endod J
September 2025
Department of Forensic Dentistry and Public Health, School of Dentistry, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil.
This systematic review examined the relationship between sickle cell disease (SCD), an inherited genetic hemoglobinopathy, and avascular pulp necrosis (APN) in intact teeth. A comprehensive search of eight electronic databases was performed up to December 2024. Eligible studies included observational or interventional designs reporting APN in intact teeth of individuals with SCD.
View Article and Find Full Text PDFAm J Physiol Heart Circ Physiol
September 2025
Hematology and Transfusion Center, University of Campinas - UNICAMP, Campinas. São Paulo, Brazil. 13083-878.
Intravascular hemolysis (IVH), a pathological process associated with various conditions, triggers inflammatory responses, yet the key molecular drivers of these responses are poorly defined, particularly within the vasculature. To explore the role of NLRP3 inflammasome- and caspase-1-dependent pathways in IVH-induced vascular dysfunction, we used models of acute and chronic IVH, alongside heme stimulation of endothelial cells, thereby isolating this disease mechanism from its etiological causes. IVH induced rapid inflammatory responses in C57BL/6J mice, including IL-1β release within 15 minutes, and NLRP3-dependent caspase-1 activation in circulating leukocytes.
View Article and Find Full Text PDFInt J Infect Dis
September 2025
Service de Médicine et Chirurgie Pédiatrique, Centre Hospitalier de Cayenne, 3 Avenue Alexis Blaise, 97300 Cayenne, Guyane Française; Centre de référence de la drépanocytose, Centre Hospitalier de Cayenne, 3 Avenue Alexis Blaise, 97300 Cayenne, Guyane Française; UFR Santé Hyacinthe BASTARAUD
Patients with sickle cell disease (SCD) infected with dengue virus are at high risk of developing severe complications. However, the optimal management approach for this patient population remains unclear. We report two cases of dengue-associated multiorgan failure in adolescents with hemoglobin SC (HbSC) disease, both of whom recovered following structured symptomatic management.
View Article and Find Full Text PDFIndian J Pediatr
September 2025
Department of Pediatric Medicine and Surgery, Cayenne Hospital, Avenue Alexis Blaise 97300 Cayenne, French Guiana, France.
Objectives: To evaluate the impact of asthma on hospitalizations for acute vaso-occlusive pain episodes in children with sickle cell disease (SCD).
Methods: A multicenter nested case-control study was conducted over a period from January 1, 2012, to December 31, 2022.
Results: The mean age of the study population was 8.
Sickle cell disease (SCD) is a hereditary blood disorder characterized by the production of abnormal hemoglobin molecules that cause red blood cells to take on a crescent or sickle shape. SCD causes excruciating pain, leading to hospitalizations and negatively affecting patients' quality of life. In transitioning to university life, students find themselves in a new environment, with demanding new domestic responsibilities and engaging in academic tasks that are perceived as different and are closely related to future success and dealing with their social life.
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