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Article Abstract
Ancestral signaling pathways serve critical roles in metazoan development, physiology, and immunity. We report an evolutionary interspecies communication pathway involving a central tick receptor termed Dome1, which acquired a mammalian cytokine receptor motif exhibiting high affinity for interferon-gamma (IFN-γ). Host-derived IFN-γ facilitates Dome1-mediated activation of the JAK-STAT pathway. This accelerates tick blood meal acquisition and development while upregulating antimicrobial components. The Dome1-JAK-STAT pathway, which exists in most Ixodid tick genomes, regulates the regeneration and proliferation of gut cells-including stem cells-and dictates metamorphosis through the Hedgehog and Notch-Delta networks, ultimately affecting vectorial competence. We highlight the evolutionary dependence of on mammalian hosts through cross-species signaling mechanisms that dually influence arthropod immunity and development.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10122270 | PMC |
| http://dx.doi.org/10.1126/science.abl3837 | DOI Listing |
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