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The strategic incorporation of the neurotransmitter dopamine around a cobaloxime core resulted in excellent electrocatalytic (rate 8400 s) and photocatalytic H production under neutral aqueous conditions. The influence of the synthetic outer coordination sphere features continues even with a phenylene-diimino-dioxime motif-coordinated cobalt core.
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http://dx.doi.org/10.1039/d2dt03509j | DOI Listing |
J Affect Disord
September 2025
Department of Radiology and Biomedical Imaging, Yale University, New Haven, CT, USA; Department of Psychiatry, Yale School of Medicine, New Haven, CT, USA; Department of Neurology, Yale University, New Haven, CT, USA. Electronic address:
Purpose: Dopamine is a neurotransmitter implicated in functions ranging from motor control to cognitive performance. In humans, dopaminergic markers have been associated with seasonal symptomatic fluctuations. Here we investigated potential seasonal variations in dopamine D2/D3 receptor availability in healthy adults using [C]PHNO positron emission tomography (PET) imaging.
View Article and Find Full Text PDFInt Dent J
September 2025
Center of Excellence in Precision Medicine and Digital Health, Geriatric Dentistry and Special Patients Care International Program, Department of Physiology, Faculty of Dentistry, Chulalongkorn University, Bangkok, Thailand; Clinic of General - Special Care and Geriatric Dentistry, Center for Dental
Background: Emerging evidence suggests a link between the oral microbiome and autism spectrum disorder (ASD), a neurodevelopmental condition characterised by social and behavioural impairments. The vast microbial reservoirs in the gut complement those of the oral cavity, suggesting a potential oral-gut-brain axis that may influence ASD and perhaps other neurological diseases, such as Parkinson's syndrome and Alzheimer's disease. For the first time, this systematic review synthesises the current knowledge of oral microbiome composition, diversity, and functionality in ASD and its potential diagnostic and therapeutic implications.
View Article and Find Full Text PDFNeurochem Res
September 2025
Biology and Health Laboratory, Faculty of Sciences, Ibn Tofail University, Kenitra, Morocco.
Parkinson's disease (PD) is characterized by impairments in motor control following the degeneration of dopamine-producing neurons located in the substantia nigra pars compacta. Environmental pesticides such as Paraquat (PQ) and Maneb (MB) contribute to the onset of PD by inducing oxidative stress (OS). This study evaluated the therapeutic efficacy of moderate physical activity (PA) on both motor and non-motor symptoms in a Wistar rat model of Paraquat and Maneb (PQ/MB) induced PD.
View Article and Find Full Text PDFACS Electrochem
September 2025
Department of Chemistry and Chemical Engineering, Chalmers University of Technology, Kemigården 4, Gothenburg 412 96, Sweden.
Carbon fiber nanotip electrodes (CFNEs) are crucial for electrochemical recordings of neurotransmission release in confined spaces, such as synapses and intracellular measurements. However, fabricating CFNEs with small surface area to minimize noise remains challenging due to inconsistent tip size control, low reproducibility, and low fabrication success rate. Here, we present a reliable, user-friendly method with high reproducibility and success rate for precise CFNE fabrication using microscopy-guided electrochemical etching of cylindrical carbon fiber microelectrodes in a potassium hydroxide droplet.
View Article and Find Full Text PDFMol Psychiatry
September 2025
Department of Psychiatry and Behavioral Neuroscience, University of Chicago, Chicago, IL, USA.
Stimulant Use Disorder (StUD) is a pervasive and extremely dangerous form of addiction for which there are currently no approved medications. Discovering treatments will require a deep understanding of the neural mechanisms underlying the behavioral effects of stimulant drugs. A major target is the mesocorticolimbic system.
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