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http://dx.doi.org/10.1002/clc.23968 | DOI Listing |
Bioorg Chem
September 2025
Post Graduate and Research Department of Botany, A.V.V.M. Sri Pushpam College (Affiliated to Bharathidasan University), Poondi 613 503, Thanjavur, India. Electronic address:
The research employed zirconyl oxychloride as a catalyst in a reaction involving pyrazole aldehyde, (thio)urea, and acetyl acetone to establish an aqueous approach for synthesizing 3,4-dihydropyrimidinone derivatives (compounds 4a-j) with potential claims as antidiabetic agents. FT-IR, HR-MS, H NMR and C NMR were employed to analyze the synthesized compounds. The HOMO-LUMO analysis was performed to evaluate the stability of the synthesized derivatives.
View Article and Find Full Text PDFBMJ Med
September 2025
Department of Prescription Data, Central Research Institute of Ambulatory Health Care, Berlin, Germany.
Objectives: To identify and quantify prescriptions after a covid-19 infection compared with other acute respiratory infections in previously healthy patients and those with chronic disease.
Design: Comparative observational study based on German routine data.
Setting: Ambulatory care of all residents in Germany with statutory health insurance (88% of the German population).
Food Res Int
November 2025
Centre for Pre-clinical Studies, Biological Sciences and Technology Division, CSIR-North East Institute of Science and Technology (NEIST), Jorhat, Assam 785006, India; AcSIR-Academy of Scientific and Innovative Research, Ghaziabad, Uttar Pradesh 201002, India. Electronic address:
This is the first report on the functional potential of Akhuni, an ethnic food of Northeast India, against diabetes. Akhuni is a traditional fermented soybean product known for its umami taste and delicacy, commonly used in the cuisine of Northeast India. Treatment with ethanolic extract of Akhuni (AKET) for 8 weeks decreased glucose levels in the blood, increased body mass and enhanced the ability to tolerate glucose dose-dependently in the streptozotocin-induced diabetic mice in comparison with the group of diabetic control mice (DBC).
View Article and Find Full Text PDFFood Res Int
November 2025
Oil Crops Research Institute of the Chinese Academy of Agricultural Sciences, Oil Crops and Lipids Process Technology National & Local Joint Engineering Laboratory, Key Laboratory of Oilseeds Processing, Ministry of Agriculture and Rural Affairs, Hubei Key Laboratory of Lipid Chemistry and Nutrition
Type 2 diabetes mellitus (T2DM) is a a complex metabolic disorder that poses a serious threat to human health. Although polyphenol extract from rapeseed meal (RMP) has demonstrated inhibitory activity against α-glucosidase, the alleviating effects on T2DM and the underlying molecular mechanisms remain largely unexplored in T2DM. In this study, the antidiabetic effects of RMP were investigated using a T2DM mouse model induced by a high-fat diet (HFD) combined with streptozotocin (STZ) administration.
View Article and Find Full Text PDFFood Res Int
November 2025
Engineering Research Center of Western Resource Innovation Medicine Green Manufacturing, Ministry of Education, School of Chemical Engineering, Northwest University, Xi'an 710069, China; Shaanxi R&D Center of Biomaterials and Fermentation Engineering, School of Chemical Engineering, Northwest Univer
In recent years, various drugs have been proven to effectively alleviate diabetes, but these drugs are associated with serious adverse reactions. Therefore, the development of safer and more effective new hypoglycemic drugs has become a global research focus. Plant-derived hypoglycemic peptides (PDHPs), due to their remarkable hypoglycemic activity and safety, have emerged as potential candidates for preventing and improving symptoms in diabetic patients.
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