Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
Objective: This study aimed to assess the efficacy and safety of adjuvant chemotherapy (ACT) after concurrent chemoradiation (CCRT) in patients with locally advanced cervical cancer (LACC) meta-analysis.
Methods: A systematic literature search of MEDLINE, PubMed, Web of Science, EMBASE, and the Cochrane Central Register of Controlled Trials was conducted from January 10, 1966 to May 20, 2022. Randomized controlled trials and observational studies comparing the CCRT alone with CCRT plus ACT were included. The literature search, quality assessment, and data extraction were conducted by two reviewers independently. The primary endpoints were 3-year rates of overall survival (OS) and progression-free survival (PFS). Complete response rate, local recurrence, distant metastasis, and adverse events were secondary outcomes. The hazard ratios (HRs) and relative risk (RR) were pooled.
Results: Nine studies with a total of 2732 patients were included in this meta-analysis, including 1411 patients in the CCRT group and 1321 in the CCRT plus ACT group. The HR for 3-year rates of OS and PFS of the CCRT group compared with the CCRT plus ACT group was 0.72 [95%confidence interval (CI) = 0.44-1.17] and 0.78 (95%CI = 0.5-1.75), respectively. No significant differences were observed between the two groups in the complete response rate (RR = 1.06, 95%CI = 0.96-1.16). However, local recurrence and distant metastasis were significantly lower in the CCRT plus ACT group than in the CCRT group (RR = 0.63, 95%CI = 0.44 -0.91 and RR = 0.64, 95%CI = 0.47-0.88). Grade 3-4 acute toxicities were more frequent in the CCRT plus ACT group (RR = 1.73, 95%CI =1.19-2.52).
Conclusion: Although associated with a decreased risk of local recurrence and distant metastasis, ACT did not significantly improve the survival rate and the complete response rate with increasing grade 3-4 acute toxicities in patients with LACC. Thus, this ACT regimen cannot be recommended for patients with LACC.
Systematic Review Registration: https://inplasy.com/inplasy-2022-9-0089/, identifier INPLASY202290089.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9768423 | PMC |
| http://dx.doi.org/10.3389/fonc.2022.997030 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Effect of radical radiotherapy dose on the prognosis of limited-stage thoracic small cell carcinoma of the esophagus: A multicenter retrospective trial from China (CHiSCEC).
J Cancer Res Ther
September 2025
Shandong Cancer Hospital and Institute, Shandong First Medical University, Shandong Academy of Medical Sciences, Jinan, China.
Background: The optimal radiation dose for the treatment of small cell carcinoma of the esophagus (SCEC) has not been established. This study aimed to investigate the treatment outcomes and toxicities in patients with limited-stage SCEC (LS-SCEC) treated by radiotherapy.
Methods: Patients with LS-SCEC from 14 institutions were retrospectively identified between December 2000 and October 2021.
Long non-coding RNA C20orf56 as a predictor of response to neoadjuvant CCRT and survival rates of rectal cancers.
Histol Histopathol
September 2025
Department of Pathology, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan.
Introduction: Colorectal cancer is the third most prevalent malignancy and the second leading cause of cancer mortality worldwide. Neoadjuvant concurrent chemoradiotherapy (CCRT) improves survival and increases curative surgery rates in rectal cancer. C20orf56, a long non-coding RNA (lncRNA), plays diverse roles in cancer, but its association with neoadjuvant CCRT response and prognosis in rectal cancer remains unexplored.
View Article and Find Full Text PDFA clinical study on the efficacy of concurrent chemoradiotherapy combined with targeted therapy and hyperthermia in patients with locally advanced cervical cancer.
Transl Oncol
September 2025
Department of Radiotherapy, The Second Hospital of Dalian Medical University, Dalian, Liaoning Province, China. Electronic address:
Objective: To explore novel therapeutic approaches for locally advanced cervical cancer (LACC), we evaluated the efficacy and safety of hyperthermia (HT) and/or targeted therapy combined with cisplatin-based concurrent chemoradiotherapy (CCRT).
Methods: This retrospective study analyzed 119 LACC patients (tumor diameter ≥4 cm) treated at our institution (Jan 2021-Oct 2024), stratified into: CCRT (n = 48), targeted therapy + CCRT (T-CCRT, n = 44), and HT + targeted therapy + CCRT (HT-T-CCRT, n = 27). Complete/objective response rates (CRR/ORR) at 3/12 months were assessed.
Effect of Limosilactobacillus reuteri Probiotic on Oral Mucositis in Patients Undergoing Head and Neck Radiation: A Randomised Trial.
Oral Dis
August 2025
Faculty of Dentistry, National University of Singapore, Singapore City, Singapore.
Objective: Limited management strategies exist for cancer therapy-induced oral mucositis (OM).
Materials And Methods: We conducted a randomised, double-blind, placebo-controlled trial to assess the efficacy and safety of Limosilactobacillus reuteri (LR) probiotic to prevent and reduce the severity of OM in head and neck cancer patients undergoing radiotherapy (RT). Patients ≥ 21 years requiring head and neck RT of ≥ 60 Gy and those undergoing concurrent chemotherapy with RT (CCRT) with no prior OM were recruited.
Concurrent chemoradiotherapy with docetaxel, cisplatin, and fluorouracil for patients with advanced external auditory canal squamous cell carcinoma: comparison with cisplatin-based concurrent chemoradiotherapy.
Eur Arch Otorhinolaryngol
August 2025
Department of Otolaryngology Head and Neck Surgery, Graduate School of Medical and Dental Sciences, Niigata University, Niigata City, Niigata, Japan.
Purpose: Concurrent chemoradiotherapy (CCRT) with docetaxel, cisplatin (CDDP), and fluorouracil (5-FU) (i.e. TPF regimen) has yielded favourable outcomes in treating advanced external auditory canal squamous cell carcinoma (EACSCC).
View Article and Find Full Text PDF