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To improve the quality of magnetic resonance (MR) image edge segmentation, some researchers applied additional edge labels to train the network to extract edge information and aggregate it with region information. They have made significant progress. However, due to the intrinsic locality of convolution operations, the convolution neural network-based region and edge aggregation has limitations in modeling long-range information. To solve this problem, we proposed a novel transformer-based multilevel region and edge aggregation network for MR image segmentation. To the best of our knowledge, this is the first literature on transformer-based region and edge aggregation. We first extract multilevel region and edge features using a dual-branch module. Then, the region and edge features at different levels are inferred and aggregated through multiple transformer-based inference modules to form multilevel complementary features. Finally, the attention feature selection module aggregates these complementary features with the corresponding level region and edge features to decode the region and edge features. We evaluated our method on a public MR dataset: Medical image computation and computer-assisted intervention atrial segmentation challenge (ASC). Meanwhile, the private MR dataset considered infrapatellar fat pad (IPFP). Our method achieved a dice score of 93.2% for ASC and 91.9% for IPFP. Compared with other 2D segmentation methods, our method improved a dice score by 0.6% for ASC and 3.0% for IPFP.
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http://dx.doi.org/10.1016/j.compbiomed.2022.106427 | DOI Listing |
Nat Aging
September 2025
Department of Clinical Molecular Biology, University of Oslo and Akershus University Hospital, Lørenskog, Norway.
Beyond their classical functions as redox cofactors, recent fundamental and clinical research has expanded our understanding of the diverse roles of nicotinamide adenine dinucleotide (NAD) and nicotinamide adenine dinucleotide phosphate (NADP) in signaling pathways, epigenetic regulation and energy homeostasis. Moreover, NAD and NADP influence numerous diseases as well as the processes of aging, and are emerging as targets for clinical intervention. Here, we summarize safety, bioavailability and efficacy data from NAD-related clinical trials, focusing on aging and neurodegenerative diseases.
View Article and Find Full Text PDFPLoS One
September 2025
Department of Economics, Cornell University, Ithaca, United States of America.
In this paper, we study the impact of momentum, volume and investor sentiment on U.S. tech sector stock returns using Principal Component Analysis-Hidden Markov Model (PCA-HMM) methodology.
View Article and Find Full Text PDFFood Res Int
November 2025
College of Animal Sciences, Zhejiang University, Hangzhou, China; Key Laboratory of Molecular Animal Nutrition (Zhejiang University), Ministry of Education, China. Electronic address:
Cultured meat is an emerging field in future food production, employing interdisciplinary strategies that integrate the food industry, tissue engineering, and biotechnology to meet global food needs. Cultivating meat from stem cells is an increasingly recognized solution to address concerns associated with animal husbandry in terms of environment, health, and ethics. Despite significant advances, substantial technical challenges persist.
View Article and Find Full Text PDFAcc Chem Res
September 2025
Division of Materials and Manufacturing Science, Graduate School of Engineering, The University of Osaka, 2-1 Yamada-oka, Suita, Osaka 565-0871, Japan.
ConspectusHydrogen spillover, the simultaneous diffusion of protons and electrons, has recently emerged as a key phenomenon in the functionalization of hydrogen in cutting-edge research fields. Its occurrence has been found to significantly impact hydrogen-related fields of science, such as catalysis, reduction, and hydrogen storage. Since the discovery of hydrogen spillover more than half a century ago, although many scientists have reported its unique properties and have attempted to utilize them, no practical advanced applications have been established yet.
View Article and Find Full Text PDFJ Fish Biol
September 2025
National Oceanic and Atmospheric Administration/NOS/NCCOS/MSE/Biogeography Branch, Silver Spring, Maryland, USA.
Despite snappers' (family Lutjanidae) commercial and ecological significance, knowledge gaps remain regarding life history, ontogeny and ecology across their range in the Caribbean and south Atlantic. There is also a need to explore the efficacy of marine protected areas (MPAs) as a tool for enhancing nursery and spawning habitat conservation for multiple snapper species. Additionally, even as hurricanes and sargassum inundation have become rising issues for coastal communities, there is a scarcity of data on how commercially important species respond to these environmental disturbances.
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