Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
Objective: Spinocerebellar ataxia type 3 (SCA3) is the most common autosomal dominant ataxia globally. No effective treatment is currently available for SCA3. Repetitive Transcranial Magnetic Stimulation (rTMS) is a non-invasive form of brain stimulation, demonstrated to improve symptoms in patients with neurodegenerative cerebellar ataxias. The present study investigated whether treatment with rTMS over the cerebellum for 15 consecutive days improved measures of ataxia in SCA3 patients.
Methods: A double-blind, prospective, randomized, sham-controlled trial was carried out on 44 SCA3 patients. Participants were randomly assigned to two groups: real or sham stimulation. Each participant underwent 30 minutes of 1Hz rTMS stimulation (a total of 900 pulses) for 15 consecutive days. The primary outcome measure was the score on the International Cooperative Ataxia Rating Scale (ICARS), and secondary outcomes were from the Scale for the Assessment and Rating of Ataxia (SARA) and the Berg Balance Scale (BBS).
Results: Nausea was the only adverse effect reported by 2 participants from the sham and real group. After 15 days of treatment, there was a significant improvement in all performance scores in both real and sham stimulation groups. However, compared to the sham group, the improvements were significantly larger in the real group for the ICARS (P = 0.002), SARA (P = 0.001), and BBS (P = 0.001).
Interpretation: A 15 days treatment with rTMS over the cerebellum improves the symptoms of ataxia in SCA3 patients. Our results suggest that rTMS is a promising tool for future rehabilitative approaches in SCA3.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.parkreldis.2022.105236 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Neurodevelopmental considerations for transcranial magnetic stimulation trials in youth.
Neuropsychopharmacology
September 2025
Department of Psychiatry & Behavioral Sciences, University of Minnesota, Minneapolis, MN, USA.
Repetitive transcranial magnetic stimulation (rTMS) is an emerging treatment for neuropsychiatric disorders that shows initial efficacy, safety, and tolerability in adolescents with treatment-resistant depression. As research expands to clinical trials testing rTMS in youth with other diagnoses and at younger ages, it is important to consider how neurodevelopmental factors might moderate or mediate rTMS effects and factor this into clinical trial design. In the current paper, we review how key domains of neurodevelopment may interact with rTMS, including neuroanatomy, neural circuit network topography, neuroplasticity, hormones, state-dependent effects, and psychosocial development.
View Article and Find Full Text PDFDynamic brain network reconfiguration following rTMS in males with cocaine use disorder.
Front Hum Neurosci
August 2025
School of Biomedical Engineering, Harbin Institute of Technology (Shenzhen), Shenzhen, China.
Cocaine use disorder (CUD) is characterized by cortico-striatal circuit dysregulation and high relapse rates, with repetitive transcranial magnetic stimulation (rTMS) emerging as a potential neuromodulatory intervention. This study investigates rTMS-induced dynamic brain network reconfigurations in 30 CUD patients using longitudinal resting-state fMRI from the SUDMEX-TMS cohort. Applying Leading Eigenvector Dynamics Analysis (LEiDA) to phase-locking states, we identified four metastable network configurations mapped to canonical resting-state networks.
View Article and Find Full Text PDFEffect of high-frequency rTMS on cognitive deficits in schizophrenia: A randomized, double blind, sham-controlled trial.
Indian J Psychiatry
August 2025
Department of Psychiatry, Serenity Clinic, New Delhi, India.
Background: Cognitive deficits significantly contribute to the disability related to schizophrenia.
Aim: We aim to evaluate the efficacy of high-frequency rTMS intervention in the improvement of cognitive symptoms in schizophrenia.
Methods: One-hundred patients of predominantly negative schizophrenia having cognitive deficits were enrolled for this randomized, sham controlled, double-blind trial.
Letter to the editor regarding: "Lack of early reduction in depression severity predicts treatment non-response with 10 Hz and accelerated theta burst repetitive transcranial magnetic stimulation in treatment-resistant depression" by Nguyen et al. (2025).
J Affect Disord
September 2025
AIZH Statistics, Melbourne, Australia. Electronic address:
Effects of repetitive transcranial magnetic stimulation over the supplementary motor area on balance and postural control in stroke patients: a randomized controlled trial.
Top Stroke Rehabil
September 2025
Department of Rehabilitation Medicine, West China Hospital, Sichuan University, Chengdu, China.
Objective: To investigate the effects of 10 Hz repetitive transcranial magnetic stimulation (rTMS) targeting the supplementary motor area (SMA) on balance and postural control in patients with stroke.
Methods: In this randomized controlled trial, 40 patients withbalance disorders were randomly assigned to either the transcranial magneticstimulation (TMS) group ( = 20) or the sham group ( = 20). Both groups underwent a two-week standardized physical therapy.