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Background: Serrated polyps have been recognized as the important premalignant lesions. In this study, we aimed to analyze the clinicopathological features of sessile serrated polyps and determine the association between sessile serrated polyps and synchronous advanced adenomas.
Methods: Consecutive patients undergoing diagnostic or therapeutic colonoscopies (including 156 681 diagnostic colonoscopies) from 2011 to 2019 were included.
Results: A total of 958 patients, including 699 (73%) males, were detected with at least 1 sessile serrated polyp, and 65.9% (n = 658) of sessile serrated polyps were located in the distal colon. Advanced serrated lesions accounted for 9.1% (n = 91) of all the sessile serrated polyp (n = 999). The types of SSP included flat type (953/999, 95.4%) and sub-pedunculated or pedunculated type (46/999, 4.6%). Meanwhile, there was no obvious evidence supporting the association between advanced adenomas and characteristics of advanced serrated lesions or sessile serrated polyps.
Conclusion: Sessile serrated polyps seem to be more frequently seen in the distal colon of men in this study. However, more evidence is required to confirm the actual distribution of sessile serrated polyp in colon among Chinese people. There is still much room for improvement of sessile serrated polyp detection rate, and more importance should be attached to sessile serrated polyp both for pathologists and endoscopists.
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http://dx.doi.org/10.5152/tjg.2022.22027 | DOI Listing |
Indian J Gastroenterol
September 2025
Department of Gastroenterology and Hepatology, Westmead Hospital, Sydney, NSW, 2145, Australia.
Endoscopic resection of pre-malignant polyps remains a cornerstone of colorectal cancer prevention. This review provides an evidence-based analysis of the current approaches to endoscopic colorectal polyp management. Cold snare resection is recommended for small and diminutive polyps.
View Article and Find Full Text PDFJ Can Assoc Gastroenterol
August 2025
Division of Gastroenterology, Montreal University Hospital Research Center (CRCHUM), Montreal, QC H2X 0C1, Canada.
Background And Study Aims: Recent research has identified an association between proximal sessile serrated lesions (SSLs) and an increased risk of advanced metachronous neoplasia (TMAN), with no significant impact from distal SSL. This study aimed to assess the risk of TMAN at follow-up colonoscopy after detecting proximal hyperplastic polyps (HP), adenomas, or their combination at the initial colonoscopy.
Methods: Medical records from patients who underwent colonoscopies in 2014 and 2015 were reviewed.
Clin Transl Gastroenterol
August 2025
Department of Gastroenterology, Hepatology & Nutrition, Digestive Disease Institute, Cleveland Clinic Foundation, Cleveland, OH.
Background: Glucagon-like peptide-1 receptor agonists (GLP-1RA) are increasingly used for managing diabetes and obesity. While they improve glycemic control, they also delay gastrointestinal motility, potentially leading to inadequate bowel preparation for colonoscopy, which can increase the risk of missed lesions. This study aims to evaluate the impact of GLP-1RA use on the quality of bowel preparation and on adenoma and sessile serrated adenoma (SSP) polyp detection.
View Article and Find Full Text PDFDig Dis Sci
August 2025
Section of Gastroenterology, Department of Medicine, Baylor College of Medicine, Houston, TX, USA.
Purpose: Multiple randomized controlled trials have shown that real-time computer-aided detection (CADe) devices can significantly increase adenoma and sessile serrated polyp detection. Unfortunately, there have been several pragmatic implementation studies that have questioned the utility of these devices in everyday practice. This study aimed to understand the effects of the pragmatic implementation of a CADe device on colonoscopy metrics at a trainee-dominated academic county hospital.
View Article and Find Full Text PDFWorld J Gastrointest Endosc
August 2025
Rural Clinical School, University of New South Wales, Port Macquarie 2444, New South Wales, Australia.
Background: Sessile serrated lesions (SSLs) are premalignant polyps implicated in up to 30% of colorectal cancers. Australia reports high SSL detection rates (SSL-DRs), yet with marked variability (3.1%-24%).
View Article and Find Full Text PDF