Publications by authors named "Clarence Kerrison"

Endoscopic resection of pre-malignant polyps remains a cornerstone of colorectal cancer prevention. This review provides an evidence-based analysis of the current approaches to endoscopic colorectal polyp management. Cold snare resection is recommended for small and diminutive polyps.

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Article Synopsis
  • Lesion size (≥40mm) is a significant factor for recurrence after endoscopic mucosal resection, and post-resection margin thermal ablation (MTA) seems to reduce this risk.
  • A study analyzed outcomes across three phases from 2009 to 2023, revealing a notable decrease in recurrence rates after implementing standardized MTA, from 13.5% to 2.1%.
  • MTA effectively equalizes recurrence rates across all polyp sizes (20-39mm, 40-59mm, ≥60mm) when used, suggesting it could be an important strategy for managing larger colorectal polyps.
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Nonlifting large nonpedunculated colorectal polyps (NL-LNPCPs) account for 15% of LNPCPs and are effectively managed by endoscopic mucosal resection (EMR) with adjunctive cold-forceps avulsion with adjuvant snare-tip soft coagulation (CAST). Recurrence rates >10% at surveillance colonoscopy are however a significant limitation. We aimed to compare the outcomes of CAST plus margin thermal ablation (MTA) versus CAST alone for NL-LNPCPs.

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Background And Aims: The efficacy of colorectal endoscopic mucosal resection (EMR) is limited by recurrence and the necessity for conservative surveillance. Margin thermal ablation (MTA) after EMR has reduced the incidence of recurrence at the first surveillance colonoscopy at 6 months (SC1). Whether this effect is durable to second surveillance colonoscopy (SC2) is unknown.

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Article Synopsis
  • Endoscopic submucosal dissection (ESD) is being considered for treating large nonpedunculated colorectal polyps (LNPCPs) to manage potential low-risk cancers, but its effectiveness in the right colon is unclear.
  • A study analyzed over 3,000 cases, finding that only 2.6% of patients who underwent endoscopic resection (ER) had cancers, with just 0.78% being classified as low-risk.
  • The results suggest that a universal ESD approach for right colon LNPCPs may not significantly improve patient outcomes due to the low prevalence of treatable low-risk cancers.
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Background: Māori have historically seen a lower rate of inflammatory bowel disease (IBD) compared to New Zealand's non-Māori population. Recent reports have shown an increasing rate of IBD among Māori patients.

Aim: We performed a study to identify the phenotypes of IBD in the Māori population.

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Background And Aims: Conventional hot snare endoscopic mucosal resection (H-EMR) is effective for the management of large (≥20 mm) non-pedunculated colon polyps (LNPCPs) however, electrocautery-related complications may incur significant morbidity. With a superior safety profile, cold snare EMR (C-EMR) of LNPCPs is an attractive alternative however evidence is lacking. We conducted a randomised trial to compare the efficacy and safety of C-EMR to H-EMR.

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Background:  Diverticular peroral endoscopic myotomy (POEM) is an alternative to surgery for the management of symptomatic thoracic esophageal diverticula. Conventionally, this requires proximal tunnel formation but a direct approach may simplify the technique. Herein, we report the outcomes of direct diverticular-POEM (DD-POEM).

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Liver cancer is among the most commonly diagnosed and least-survivable cancers in New Zealand. There are stark disparities between the Indigenous Māori population in incidence of and mortality from liver cancer relative to non-Māori. In this review, we have summarised the key risk factors for liver cancer, and the key activities undertaken in New Zealand, over time, to control this disease, with a focus on how risk factors and interventions aimed at reducing them differentially impact Māori.

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In New Zealand, there are known disparities between the Indigenous Māori and the majority non-Indigenous European populations in access to cancer treatment, with resulting disparities in cancer survival. There is international evidence of ethnic disparities in the distance travelled to access cancer treatment; and as such, the aim of this paper was to examine the distance and time travelled to access surgical care between Māori and European liver and stomach cancer patients. We used national-level data and Geographic Information Systems (GIS) analysis to describe the distance travelled by patients to receive their first primary surgery for liver or stomach cancer, as well as the estimated time to travel this distance by road, and the surgical volume of hospitals performing these procedures.

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Inflammatory bowel diseases (IBD) are chronic, inflammatory diseases that are increasingly prevalent in New Zealand. Previous regional studies describe significantly lower rates of IBD in Māori compared to non-Māori. This article reports the prevalence and incidence of IBD at Lakes District Health Board, and discusses potential contributing factors to the observed increasing incidence rates in Māori.

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Article Synopsis
  • Liver and stomach cancers are significant causes of cancer death for Māori in New Zealand, with notable disparities in survival rates compared to the European population.
  • The study analyzed data from the New Zealand Cancer Registry (2007-2019) to assess access to surgical treatments for Māori and Europeans with liver and stomach cancers.
  • Findings revealed lower access to liver transplants for Māori, a higher need for palliative care in stomach cancer cases, and differences in the timing of surgery, though overall access to curative treatment was similar for both groups.
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In the public sphere, issues are like icebergs. This somewhat hackneyed metaphor illustrates that, while one facet of an issue is perceived, what is not seen is the hidden substructure of power and culture that form and reinforce it, buoying the issue to prominence above the surface.

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