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Article Abstract
Objective And Design: The heterogeneity of response to SARS-CoV-2 infection is directly linked to the individual genetic background. Genetic variants of inflammasome-related genes have been pointed as risk factors for several inflammatory sterile and infectious disease. In the group of inflammasome receptors, NLRP1 stands out as a good novel candidate as severity factor for COVID-19 disease.
Methods: To address this question, we performed an association study of NLRP1, DPP9, CARD8, IL1B, and IL18 single nucleotide variants (SNVs) in a cohort of 945 COVID-19 patients.
Results: The NLRP1 p.Leu155His in the linker region, target of viral protease, was significantly associated to COVID-19 severity, which could contribute to the excessive cytokine release reported in severe cases.
Conclusion: Inflammasome genetic background contributes to individual response to SARS-CoV-2.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9684769 | PMC |
| http://dx.doi.org/10.1007/s00011-022-01670-3 | DOI Listing |
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