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Article Abstract
A new andrographolide-based terminal alkyne was synthesized in good yield from -andrographolide , obtained from a natural compound andrographolide , which in turn was isolated from the leaves of the plant . Copper(I)-catalyzed azide-alkyne cycloaddition reaction of alkyne with -sugars furnished a library of andrographolide-fastened triazolyl glycoconjugates in good yields. The structures of these semisynthetic andrographolide derivatives were established by Fourier transform infrared, NMR, and mass spectroscopy. The compounds were further evaluated against Alzheimer's disease (AD) using a scopolamine (SCOP)-induced memory impairment mice model. It was observed that antioxidant and anticholinesterase properties of these compounds contribute significantly toward their remarkable potential to improve cognitive functioning.
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