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Article Abstract
expresses various virulence factors to adapt to hostile environments and infect susceptible hosts. This study investigated the regulatory network of the BfmRS two-component and AbaIR quorum sensing (QS) systems in the expression of virulence-associated genes in ATCC 17978. The Δ mutant exhibited a significant decrease in surface motility, which presumably resulted from the low expression of and - gene cluster. The Δ mutant displayed a significant reduction in biofilm and pellicle formation due to the low expression of operon. The deletion of did not affect the expression of or . However, the expression of and was upregulated in the Δ mutant. The Δ mutant also produced more autoinducers than did the wild-type strain, suggesting that BfmR negatively regulates the AbaIR QS system. The Δ mutant exhibited no autoinducer production in the bioassay system. The expression of the gene cluster was downregulated in the Δ mutant, whereas the expression of operon was upregulated in this mutant with a high cell density. In conclusion, for the first time, we demonstrated that the BfmRS-AbaIR QS system axis regulated the expression of virulence-associated genes in . This study provides new insights into the complex network system involved in the regulation of virulence-associated genes underlying the pathogenicity of .
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9657202 | PMC |
| http://dx.doi.org/10.3390/ijms232113136 | DOI Listing |
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